Prognostic factors and outcome of resected patients for gastrointestinal stromal tumors

Antonio Chiappa, Andrew P. Zbar, Roberto Biffi, Emilio Bertani, Ugo Pace, Giancarlo Pruneri, Paolo Della Vigna, Carmine Grassi, Manlio Valerio, Davide Poldi, Bruno Andreoni

Research output: Contribution to journalArticlepeer-review


Background/Aims: The aim of this study was to analyze the outcome of 33 patients with primary gastrointestinal stromal tumors (GISTs) who were observed and treated in a single teaching hospital and followed up prospectively. Methodology: Thirty-three GISTs patients (21 male; 12 female; mean age: 57±12 years; range: 23-76 years) between June 1994 and October 2004, were reviewed retrospectively. Patient, tumor, and treatment variables were analyzed to identify patterns of tumor relapse and factors affecting survival. Results: Of 33 patients, 30 patients (91%) had primary tumor without metastasis, and all of them underwent complete surgical resection of gross disease. Three patients (9%) had metastasis. Among patients radically resected, the 5-year actuarial survival rate was 85%, and the disease-free survival was 76%. Among patients resected for cure, there were 6 recurrences. The mean time to recurrence was 22±11 months (range: 4-36 months), and liver was the prevalent site for relapsing disease (n=5; 83%). After recurrence, survival at 2 and 3 years was 44% and 0%, respectively. Conclusions: GISTs are uncommon sarcomas. Tumor recurrence tends to be intra-abdominal. Investigational protocols are indicated to reduce the rate of recurrence after resection and to improve the outcome for patients with GIST.

Original languageEnglish
Pages (from-to)693-696
Number of pages4
Issue number75
Publication statusPublished - Apr 2007


  • Gastrointestinal stromal tumors (GIST)
  • Immunohistochemical staining
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Gastroenterology


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