Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa

D. Marin, S. Marktel, M. Bua, R. M. Szydlo, A. Franceschino, I. Nathan, I. Foot, C. Crawley, T. Nakorn Nakorn, E. Olavarria, A. Lennard, A. Neylon, S. G. O'Brien, J. M. Goldman, J. F. Apperley

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed clinical results in 145 patients with chronic myeloid leukaemia in chronic phase who satisfied criteria for interferon-α failure and were thus eligible for treatment with imatinib at the Hammersmith Hospital. We used univariate and multivariate analyses to develop a risk score based on features defined after treatment for 3 months. We identified a low neutrophil count and poor cytogenetic response (

Original languageEnglish
Pages (from-to)1448-1453
Number of pages6
JournalLeukemia
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

Keywords

  • Chronic myeloid leukaemia
  • Cytogenetic response
  • Imatinib mesylate
  • Neutropenia
  • Prognostic factors

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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