Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma

Gösta Gahrton, Sante Tura, Per Ljungman, Joan Bladé, Lena Brandt, Michele Cavo, Thierry Façon, Alois Gratwohl, Anton Hagenbeek, Peter Jacobs, Antonio De Laurenzi, M. Van Lint, Mauricette Michallet, Jukka Nikoskelainen, Josy Reiffers, Diana Samson, Leo Verdonck, Theo De Witte, Liisa Volin

Research output: Contribution to journalArticlepeer-review


Purpose: To analyze prognostic factors for allogeneic bone marrow transplantation (BMT) in multiple myeloma. Patients and Methods: One hundred sixty-two reports of allogeneic matched sibling-donor transplants in multiple myeloma received by the European Group for Blood and Marrow Transplantation (EBMT) registry between 1983 and early 1993 were analyzed for prognostic factors. End points were complete remission, survival, and duration of complete remission. Results: Following BMT, 44% of all patients and 60% of assessable patients entered complete remission. The overall actuarial survival rate was 32% at 4 years and 28% at 7 years. The overall relapse- free survival rate of 72 patients who were in complete remission after BMT was 34% at 6 years. Favorable pretransplant prognostic factors for survival were female sex (41% at 4 years), stage I disease at diagnosis (52% at 4 years), one line of previous treatment (42% at 4 years), and being in complete remission before conditioning (64% at 3 years). The subtype immunoglobulin A (IgA) myeloma and a low β2-microglobulin level (<4 g/L) also tended to have a favorable prognostic impact. The most important posttransplant prognostic factor was to enter a complete remission. Grade III to IV graft-versus-host disease (GVHD) was associated with poor survival. Conclusion: Patients with a low tumor burden who respond to treatment before BMT and are transplanted after first-line therapy have the best prognosis following BMT.

Original languageEnglish
Pages (from-to)1312-1322
Number of pages11
JournalJournal of Clinical Oncology
Issue number6
Publication statusPublished - Jun 1995

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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