Prognostic factors in elderly patients with malignant pleural mesothelioma: Results of a multicenter survey

G. L. Ceresoli, F. Grosso, P. A. Zucali, M. Mencoboni, G. Pasello, C. Ripa, D. Degiovanni, M. Simonelli, A. Bruzzone, C. Dipietrantonj, E. Piccolini, G. D. Beretta, A. G. Favaretto, L. Giordano, A. Santoro, M. Botta

Research output: Contribution to journalArticle

Abstract

Background:The incidence of malignant pleural mesothelioma (MPM) in elderly patients is increasing. There are no specific guidelines for their management.Methods:The clinical records of elderly patients (≥70 years old) with MPM referred from January 2005 to November 2011 to six Italian Centres were reviewed. Age, gender, histology, International Mesothelioma Interest Group (IMIG) stage, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), Charlson Comorbidity Index (CCI) and treatment modalities were analysed and correlated to overall survival (OS).Results:In total, 241 patients were identified. Charlson Comorbidity Index was ≥1 in 92 patients (38%). Treatment was multimodality therapy including surgery in 18, chemotherapy alone in 180 (75%) and best supportive care in 43 cases (18%). Chemotherapy was mainly pemetrexed based. Median OS was 11.4 months. Non-epithelioid histology (HR 2.32; 95% CI 1.66-3.23, P

Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalBritish Journal of Cancer
Volume111
Issue number2
DOIs
Publication statusPublished - Jul 15 2014

Keywords

  • Charlson Index
  • comorbidity
  • elderly
  • pemetrexed
  • pleural mesothelioma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Ceresoli, G. L., Grosso, F., Zucali, P. A., Mencoboni, M., Pasello, G., Ripa, C., Degiovanni, D., Simonelli, M., Bruzzone, A., Dipietrantonj, C., Piccolini, E., Beretta, G. D., Favaretto, A. G., Giordano, L., Santoro, A., & Botta, M. (2014). Prognostic factors in elderly patients with malignant pleural mesothelioma: Results of a multicenter survey. British Journal of Cancer, 111(2), 220-226. https://doi.org/10.1038/bjc.2014.312