Prognostic factors in FIGO stage Ib, IIa cervical cancer

F. Landoni, M. Regallo, A. Lissoni, B. Di Stasi, R. Milani, P. Perego, C. Mangioni

Research output: Contribution to journalArticlepeer-review


Based on an analysis of the literature data and a series of 125 consecutive cases treated from 1982 to 1986, the authors examine the prognostically significant factors in Stage Ib, IIa cervical cancer. Tumor volume, nodal metastases and myometrium invasion depth are among the major risk factors detected at the examination of the surgical specimen. Other parameters having a more debatable prognostic significance are age, histotype, differentiation grade, growth modality of the primary tumor, penetration of the lymphatic spaces, characteristics of the parvicellular infiltrate at the level of the tumor invasion front and nodes. The main purpose of the study on risk factors is to select the cases worthy of adjuvant postoperative treatments. A relevant fraction of the patients submitted to radical surgery present prognostically unfavourable factors. Up to now postoperative radiotherapy has had a determining role in the treatment of these cases. The introduction of chemotherapy may contribute in improving the survival of patients with a major risk of pelvic relapse and/or distant metastases.

Original languageEnglish
Pages (from-to)75-87
Number of pages13
JournalCervix and the Lower Female Genital Tract
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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