Prognostic factors in head and neck oncology: A critical appraisal for use in clinical practice

F. Chiesa, N. Tradati, S. Mauri, L. Calabrese, R. Grigolato, G. Giugliano, S. Zurrida, E. Chiesa, M. Squadrelli, G. Viale, E. Maiorano

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An ideal prognostic factor would provide information about the biological behaviour of a tumour, permitting the prediction of the outcome and response to therapy. Nowadays there is a considerable confusion concerning the value, significance and use of the know prognostic factors in head and neck cancer. Material and Methods: A meta-analysis of works published in literature between 1993 and August 1997 on prognostic factors in head and neck oncology was carried out. Results: Prognostic factors were analysed and classifield according to Wennenberg in the following groups: patient-related factors, tumour-related factors and factors predicting response to therapy. Conclusions: We propose a classification of prognostic factors in head and neck cancer according to their significance and reliability: factors of proven significance and experimental factors. The classification might be useful to select guidelines to use in clinical practice.

Original languageEnglish
Pages (from-to)4769-4776
Number of pages8
JournalAnticancer Research
Volume18
Issue number6 B
Publication statusPublished - 1998

Keywords

  • Clinical practice
  • Head and neck cancer
  • Predictive factors
  • Prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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