Prognostic factors in Hungarian breast cancer patients

Edit Nádasi, Béla Anga, János Sándor, Judit Megyesi, Dezso Kelemen, Marcella Mottolese, Pier Giorgio Natali, Géza Hegedus, István Arany, István Ember

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Breast cancer is the most common cancer among women, with variable outcomes, justifying a continuous search for new parameters to predict accurate prognosis and indicate suitable adjuvant therapy for patients. Materials and Methods: Fourty-four stage I-III breast cancer specimens were investigated immunohistochemically for the expression of cyclooxygenase-2 enzyme (COX-2), hormone receptors, tumor suppressor gene p53, oncogene HER2 and proliferation marker Ki-67. Additionally, twelve specimens were also investigated for the presence of the phosphorylated extracellular signal-regulated kinase (pERK). Results: It was demonstrated that expressions of biological markers were related to each other (ER to p53 and Ki-67, COX-2 to ER, PgR, Ki-67 and p53, Ki-67 to p53 and PgR, p53 to PgR). Conclusion: Our data indicate that concomitant immunohistochemical evaluation of cyclooxygenase-2, hormone receptors, p53 and Ki-67 may be of clinical value in determining an accurate prognosis.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalAnticancer Research
Volume27
Issue number1 A
Publication statusPublished - Jan 2007

Keywords

  • Activated extracellular signal-regulated kinase
  • Breast cancer
  • Immunohistochemistry
  • Odds ratio
  • Prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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