Prognostic factors in node positive primary breast cancer patients treated with adjuvant CMF

E. Campora, P. Pronzato, D. Amoroso, G. F. Bertelli, M. Venturini, E. Baldini, I. Brunetti, M. R. Sertoli, P. Conte, R. Rosso

Research output: Contribution to journalArticle

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Abstract

The influence of various patient and disease-related parameters on survival (S) and disease-free survival (DFS) in 217 node positive primary breast cancer patients treated with surgery followed by adjuvant i.v. cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) was evaluated by urivariate and multivariate analyses. Five year actuarial S and DFS were 73.3% and 54.8%, respectively. Univariate analysis revealed that patient age, number of involved axillary nodes and ER status had a significant impact on both S and DFS. PgR positive tumors had improved DFS but no S difference was observed. Menopausal status predicted S but not DFS. Primary tumor size and CMF-induced amenorrhea did not predict disease outcome. Multivariate analysis demonstrated that only degree of nodal involvement and PgR status had independent significant impact on prognosis. Both S and DFS are significantly influenced by the number of involved nodes, whereas improved DFS but not S was evident in patients with PgR positive tumors.

Original languageEnglish
Pages (from-to)1555-1558
Number of pages4
JournalAnticancer Research
Volume12
Issue number5
Publication statusPublished - 1992

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Methotrexate
Fluorouracil
Cyclophosphamide
Disease-Free Survival
Breast Neoplasms
Multivariate Analysis
Neoplasms
Amenorrhea
Survival

Keywords

  • Breast cancer
  • CMF
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Campora, E., Pronzato, P., Amoroso, D., Bertelli, G. F., Venturini, M., Baldini, E., ... Rosso, R. (1992). Prognostic factors in node positive primary breast cancer patients treated with adjuvant CMF. Anticancer Research, 12(5), 1555-1558.

Prognostic factors in node positive primary breast cancer patients treated with adjuvant CMF. / Campora, E.; Pronzato, P.; Amoroso, D.; Bertelli, G. F.; Venturini, M.; Baldini, E.; Brunetti, I.; Sertoli, M. R.; Conte, P.; Rosso, R.

In: Anticancer Research, Vol. 12, No. 5, 1992, p. 1555-1558.

Research output: Contribution to journalArticle

Campora, E, Pronzato, P, Amoroso, D, Bertelli, GF, Venturini, M, Baldini, E, Brunetti, I, Sertoli, MR, Conte, P & Rosso, R 1992, 'Prognostic factors in node positive primary breast cancer patients treated with adjuvant CMF', Anticancer Research, vol. 12, no. 5, pp. 1555-1558.
Campora E, Pronzato P, Amoroso D, Bertelli GF, Venturini M, Baldini E et al. Prognostic factors in node positive primary breast cancer patients treated with adjuvant CMF. Anticancer Research. 1992;12(5):1555-1558.
Campora, E. ; Pronzato, P. ; Amoroso, D. ; Bertelli, G. F. ; Venturini, M. ; Baldini, E. ; Brunetti, I. ; Sertoli, M. R. ; Conte, P. ; Rosso, R. / Prognostic factors in node positive primary breast cancer patients treated with adjuvant CMF. In: Anticancer Research. 1992 ; Vol. 12, No. 5. pp. 1555-1558.
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