Prognostic factors in non-Hodgkin's lymphomas

Paolo G. Gobbi, Giovanni Ricevuti, Carlo Balduini, Carla Cavalli, Adele Gendarini, Maurizio Bonfichi, Salvatore C. Rizzo, Edoardo Ascari

Research output: Contribution to journalArticle

Abstract

Prognostic factors were investigated in 67 patients with non-Hodgkin's lymphomas, homogeneously staged and treated (COP or CHOP according to low or high malignant histotype). A large number of parameters were scrutinized in order to recognize those exhibiting a prognostic value regarding length of survival. All the parameters that singly appeared to influence survival were entered into a multiple regression factor analysis. The erythrocyte sedimentation rate (ESR), higher or lower than 35 mm at the 1st h, better discriminated the groups of patients surviving or not at a given time. The histologic type, according to the Kiel classification of malignancy, was the second best prognosticator when a short-term prediction was requested (survival or death after no more than 2.5 years), but showed insufficient statistical weight for predicting longer survivals (> 4 years). Stage seemed to be the third best prognosticator for the first years of survival, but only the second best for longer survivals. Other parameters had very low prognostic importance when compared with those above. The results were substantially confirmed by 28 other patients, taken as controls. The importance that such a simple and easy test as ESR may be adequate with regard to prognosis is emphasized.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalActa Haematologica
Volume74
Issue number2
DOIs
Publication statusPublished - 1985

Keywords

  • Erythrocyte sedimentation rate
  • Histotype
  • Non-Hodgkin's lymphomas
  • Prognosis
  • Stage

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Gobbi, P. G., Ricevuti, G., Balduini, C., Cavalli, C., Gendarini, A., Bonfichi, M., Rizzo, S. C., & Ascari, E. (1985). Prognostic factors in non-Hodgkin's lymphomas. Acta Haematologica, 74(2), 86-91. https://doi.org/10.1159/000206174