Prognostic factors in patients with hepatocellular carcinoma submitted to chemoembolization

Marco Colleoni, Guido Liessi, Giorgio Mastrapasqua, Luca Boni, Patrizia Nelli, Giovanni Vicario, Gigliola Sgarbossa, Francesca Pancheri, Paolo Manente

Research output: Contribution to journalArticle

Abstract

The prognosis of unresectable hepatocellular carcinoma is poor. Encouraging response rates have been reported with chemoembolization, but no survival advantage has been demonstrated. Assessment of the impact of the treatment modality on prognosis is complicated by a poor understanding of the prognostic factors in the disease. We therefore evaluated, through univariate and multivariate analysis, the role on prognosis of 16 variables in 63 patients submitted to chemoembolization. Patients were treated with epirubicin (50 mg) plus ethiodized oil and gelatin sponge (22 cases) or with a new program combining i.a. chemotherapy with chemoembolization (41 cases) as follows: L-leucovorin, 100 mg/m 2 i.v.; fluorouracil, 800 mg/m 2 i.a.; carboplatin, 250 mg/m 2 i.a. Chemoembolization with mitoxantrone, 10 mg/m 2, plus ethiodized oil and gelatine sponge was performed immediately after. Median survival for the whole group of patients was 294 days. A multivariate analysis showed a highly significant influence on survival for Child's status (p=0.002) and for TNM stage (p=0.01). Median survival for patients with Child's A disease was 13.9 months and for patients with TNM stage I-II disease 19 months. In conclusion, our data suggest that patients with limited disease and adequate liver function have a longer survival after chemoembolization.

Original languageEnglish
Pages (from-to)1025-1028
Number of pages4
JournalOncology Reports
Volume4
Issue number5
Publication statusPublished - Sep 1997

Keywords

  • Chemoembolization
  • Hepatocellular carcinoma
  • Intra-arterial chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Colleoni, M., Liessi, G., Mastrapasqua, G., Boni, L., Nelli, P., Vicario, G., Sgarbossa, G., Pancheri, F., & Manente, P. (1997). Prognostic factors in patients with hepatocellular carcinoma submitted to chemoembolization. Oncology Reports, 4(5), 1025-1028.