Fattori prognostici in 170 pazienti con epilessia temporale mesiale (ETM)

Translated title of the contribution: Prognostic factors in patients with mesial temporal lobe epilepsy (MTLE). A preliminary study

F. Pittau, F. Bisulli, L. Licchetta, I. Naldi, P. Avoni, A. Parmeggiani, M. Santucci, J. E. Fares, R. Mai, L. Tassi, A. Gambardella, A. Quattrone, A. Baruzzi, P. Tinuper

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: aim of this study is to disclose familial, clinical and neuroradiological factors correlated to prognosis in patients with mesial temporal lobe epilepsy (MTLE). Method: 170 MTLE patients were studied for family history, clinical findings, instrumental data (EEG, Video-EEG, neuro-imaging) and outcome. This population was divided into lesional (LES: 43.5%) and non-lesional (N-LES: 56.5%) groups. Results: among LES 51% were drug-resistant (DR) and 49% responsive (N-DR). Mesial temporal sclerosis (MTS) was present in 58% of N-DR and in 71% of DR patients. Among 48 pts with MTS 33% had presented with febrile convulsions (FC) during childhood in the N-DR group versus 39% in the DR one. Familial and sporadic cases were equally present in DR and N-DR groups. Among N-LES 18% had FC: 34% were DR and 66% N-DR. CF antecedents were 40% and 6% respectively. Familial cases were 3% in DR group and 41% in N-DR one. Conclusions: this preliminary study shows that MTS is not a negative prognostic factor. A positive family history of epilepsy is a favourable prognostic factor in N-LES and LES pts. FC are associated with MTS, but do not themselves constitute a negative factor.

Translated title of the contributionPrognostic factors in patients with mesial temporal lobe epilepsy (MTLE). A preliminary study
Original languageItalian
Pages (from-to)109-110
Number of pages2
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number133-134
Publication statusPublished - Jul 2006

ASJC Scopus subject areas

  • Clinical Neurology

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