Purpose: aim of this study is to disclose familial, clinical and neuroradiological factors correlated to prognosis in patients with mesial temporal lobe epilepsy (MTLE). Method: 170 MTLE patients were studied for family history, clinical findings, instrumental data (EEG, Video-EEG, neuro-imaging) and outcome. This population was divided into lesional (LES: 43.5%) and non-lesional (N-LES: 56.5%) groups. Results: among LES 51% were drug-resistant (DR) and 49% responsive (N-DR). Mesial temporal sclerosis (MTS) was present in 58% of N-DR and in 71% of DR patients. Among 48 pts with MTS 33% had presented with febrile convulsions (FC) during childhood in the N-DR group versus 39% in the DR one. Familial and sporadic cases were equally present in DR and N-DR groups. Among N-LES 18% had FC: 34% were DR and 66% N-DR. CF antecedents were 40% and 6% respectively. Familial cases were 3% in DR group and 41% in N-DR one. Conclusions: this preliminary study shows that MTS is not a negative prognostic factor. A positive family history of epilepsy is a favourable prognostic factor in N-LES and LES pts. FC are associated with MTS, but do not themselves constitute a negative factor.
|Translated title of the contribution||Prognostic factors in patients with mesial temporal lobe epilepsy (MTLE). A preliminary study|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - Jul 2006|
ASJC Scopus subject areas
- Clinical Neurology