Prognostic factors in stage IV ovarian carcinoma treated with platinum-based regimens

L. Repetto, S. Chiara, M. Pace, T. Guido, M. Bruzzone, C. Oliva, C. Murolo, P. F. Conte, R. Rosso

Research output: Contribution to journalArticlepeer-review

Abstract

Eight factors were analyzed for prognostic significance in univariate analyses in a series of 76 women with stage IV ovarian carcinoma treated with combination chemotherapies including cisplatin or carboplatin. The clinical objective and pathologic complete response rates were 51.2% and 27.3%, respectively. Median overall survival and progression-free survival were 15 and 7 months, respectively. No variables reached statistical significance. Trends toward better survival were noted for grades 1 and 2 for the adriamycin-containing regimen. Using progression-free survival as an end point, significant prognostic factors included complete clinical or pathologic response. Our data confirm that the standard approach is unlikely to modify the clinical outcome of stage IV ovarian cancer. New treatment modalities including high-dose-intensity regimens and neo-adjuvant chemotherapy delivered before surgery could improve clinical results. Moreover, biologic characterization of ovarian tumors may provide information to design specifically targeted treatment.

Original languageEnglish
Pages (from-to)274-277
Number of pages4
JournalTumori
Volume76
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research

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