Prognostic factors in surgical resection of sacral chordoma

Andrea Angelini, Elisa Pala, Teresa Calabrò, Marco Maraldi, Pietro Ruggieri

Research output: Contribution to journalArticlepeer-review


Background and objectives The best treatment of sacral chordoma is surgical resection, nowadays associated with optimized radiation therapy. We analysed 1) the oncologic outcome in a large series; 2) the effect of previous intralesional surgery, resection level, tumor volume and margins on survivorship to local recurrence (LR) and 3) the complication rate. Methods We reviewed 71 patients with sacral chordomas. Forty-eight resections were proximal to S3. Mean tumor volume was 535 cm3. Eleven received previous intralesional surgery elsewhere. Margins were wide in 44 resections, wide-contaminated in 11, marginal in 9 and intralesional in 7. Results Overall survival was 92%, 65% and 44% at 5, 10 and 15 years. At a mean of 9.5 years 37 were NED (54.4%), 23 died with disease (33.8%) and 8 were alive with disease (11.7%). Relapses included 15 LRs, 6 distant metastases, 17 both. LR rate was significantly higher in patients with previous surgery (p=0.0217), with inadequate margins (p= 0.0339) and large tumors(p

Original languageEnglish
Pages (from-to)344-351
Number of pages8
JournalJournal of Surgical Oncology
Issue number4
Publication statusPublished - Sep 1 2015


  • chordoma
  • prognostic factors
  • resection
  • sacral surgery
  • sacrum
  • tumor

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Medicine(all)


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