Prognostic factors of cervical lymph node metastasis in head and neck squamous cell carcinoma

Mauro Magnano, Antonella De Stefani, Walter Lerda, Antonio Usai, Riccardo Ragona, Mario Bussi, Giorgio Cortesina

Research output: Contribution to journalArticlepeer-review


Aims and background: The metastatic spread of squamous cell carcinoma of the head and neck (SCCHN) to the cervical lymph nodes is a negative prognostic factor in terms of survival. We have used multivariate analysis to identify the possible prognostic significance of a number of clinical and pathological characteristics in relation to possible involvement of the cervical lymph nodes in a series of 396 patients. Method: 396 patients with SCCHN were studied. Variables regarding the patient, the carcinoma and histology were analysed by multivariate analysis using BMDP's PLR programme. Results: Some variables appear to represent predisposing factors for tumor spread to the lymph nodes: tumor site (supraglottic larynx: P=0.005; base of the tongue: P=0.02; hypopharynx: P=0.02), grading (P=0.001), and a number of histological parameters (lower degree of histological differentiation: P=0.001; vascular permeation: P=0.04; perineural invasion: P

Original languageEnglish
Pages (from-to)922-926
Number of pages5
Issue number6
Publication statusPublished - Nov 1997


  • Head and neck
  • Lymph node metastasis
  • Risk factors
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research


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