Prognostic factors of lung cancer in lymphoma survivors (the LuCiLyS study)

The LuCiLyS study group, Alfonso Fiorelli, Antonio D'Andrilli, Annalisa Carlucci, Giovanni Vicidomini, Domenico Loizzi, Nicoletta Pia Ardò, Rita Daniela Marasco, Luigi Ventura, Luca Ampollini, Paolo Carbognani, Giovanni Bocchialini, Filippo Lococo, Massimiliano Paci, Teresa Severina Di Stefano, Francesco Ardissone, Matteo Gagliasso, Paolo Mendogni, Lorenzo Rosso, Alessandra MazzuccoCamilla Vanni, Beatrice Trabalza Marinucci, Rossella Potenza, Alberto Matricardi, Mark Ragusa, Valentina Tassi, Marco Anile, Camilla Poggi, Nicola Serra, Antonello Sica, Mario Nosotti, Francesco Sollitto, Federico Venuta, Erino Angelo Rendina, Francesco Puma, Mario Santini

Research output: Contribution to journalArticlepeer-review


Background: Second cancer is the leading cause of death in lymphoma survivors, with lung cancer representing the most common solid tumor. Limited information exists about the treatment and prognosis of second lung cancer following lymphoma. Herein, we evaluated the outcome and prognostic factors of Lung Cancer in Lymphoma Survivors (the LuCiLyS study) to improve the patient selection for lung cancer treatment. Methods: This is a retrospective multicentre study including consecutive patients treated for lymphoma disease that subsequently developed non-small cell lung cancer (NSCLC). Data regarding lymphoma including age, symptoms, histology, disease stage, treatment received and lymphoma status at the time of lung cancer diagnosis, and data on lung carcinoma as age, smoking history, latency from lymphoma, symptoms, histology, disease stage, treatment received, and survival were evaluated to identify the significant prognostic factors for overall survival. Results: Our study population included 164 patients, 145 of which underwent lung cancer resection. The median overall survival was 63 (range, 58-85) months, and the 5-year survival rate 54%. At univariable analysis no-active lymphoma (HR: 2.19; P=0.0152); early lymphoma stage (HR: 1.95; P=0.01); adenocarcinoma histology (HR: 0.59; P=0.0421); early lung cancer stage (HR: 3.18; P<0.0001); incidental diagnosis of lung cancer (HR: 1.71; P<0.0001); and lung cancer resection (HR: 2.79; P<0.0001) were favorable prognostic factors. At multivariable analysis, no-active lymphoma (HR: 2.68; P=0.004); early lung cancer stage (HR: 2.37; P<0.0001); incidental diagnosis of lung cancer (HR: 2.00; P<0.0001); and lung cancer resection (HR: 2.07; P<0.0001) remained favorable prognostic factors. Patients with non-active lymphoma (n=146) versus those with active lymphoma (n=18) at lung cancer diagnosis presented better median survival (64 vs. 37 months; HR: 2.4; P=0.02), but median lung cancer specific survival showed no significant difference (27 vs. 19 months; HR: 0.3; P=0.17). Conclusions: The presence and/or a history of lymphoma should not be a contraindication to resection of lung cancer. Inclusion of lymphoma survivors in a lung cancer-screening program may lead to early detection of lung cancer, and improve the survival.

Original languageEnglish
Pages (from-to)90-102
Number of pages13
JournalTranslational Lung Cancer Research
Issue number1
Publication statusPublished - Feb 1 2020


  • Lung cancer
  • Lymphoma
  • Second primary tumor

ASJC Scopus subject areas

  • Oncology

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