Fattori prognostici nel trattamento del carcinoma del collo dell'utero negli stadi IB-IIA: Studio retrospettivo

Translated title of the contribution: Prognostic factors of stage IB-IIA cervical carcinoma: A retrospective study

Marilena Sacco, Maria Tessa, Monica Rampino, Riccardo Ragona, Cristina Origlia, Elena Del Mastro, Paolo Rotta

Research output: Contribution to journalArticle

Abstract

January, 1977, to December, 1990, 311 patients with stage IB-IIA cervix carcinoma were treated at the Radiotherapy Department of the University of Turin. The distribution by stage was: 232 T1b (74.6%) and 79 T2a (25.4%). One hundred and eighty-nine patients (77% T1b-23% T2a) underwent preoperative radiotherapy, 63 patients (58% T1b-42% T2a) radiotherapy alone and 59 (85% T1b-15% T2a) postoperative radiotherapy. The first group of patients was treated according to three treatment protocols, based on different surgical procedures. During the median follow-up period of 86 months (82.6% of the patients underwent a minimum 3-year follow-up), 55 locoregional relapses (17%) and 21 extrapelvic metastases (7%) were observed. The 5-year NED survival rate and local control was 80%. The prognostic factors which significantly influenced survival in the univariate analysis, were: disease stage (p < .01), age (p < .05), the period between first symptom and therapy (p = .01), treatment protocols (radiotherapy combined with surgery versus radiation therapy alone: p < .05), residual disease after brachytherapy (p < .01), nodal status (p < .00001). In the radiotherapy alone group, the total dose influence on survival was not statistically significant (p = .12). In our series, histology and surgical procedures did not seem to influence prognosis. In the multivariate analysis, treatment protocol, age and residual disease after brachytherapy did not influence the prognosis, whereas the total dose of radiotherapy, pain (as first symptom) and Wertheim-Meigs surgery approach are prognostic factors. Severe late-effects were 17: 13 in the radiotherapy plus surgery protocol and 4 in the radiotherapy alone protocol. The incidence of major complications seems to correlate with surgical impact.

Original languageItalian
Pages (from-to)764-773
Number of pages10
JournalRadiologia Medica
Volume93
Issue number6
Publication statusPublished - Jun 1997

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Radiotherapy
Retrospective Studies
Carcinoma
Clinical Protocols
Brachytherapy
Survival
Cervix Uteri
Histology
Multivariate Analysis
Survival Rate
Neoplasm Metastasis
Recurrence
Pain
Incidence

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Sacco, M., Tessa, M., Rampino, M., Ragona, R., Origlia, C., Del Mastro, E., & Rotta, P. (1997). Fattori prognostici nel trattamento del carcinoma del collo dell'utero negli stadi IB-IIA: Studio retrospettivo. Radiologia Medica, 93(6), 764-773.

Fattori prognostici nel trattamento del carcinoma del collo dell'utero negli stadi IB-IIA : Studio retrospettivo. / Sacco, Marilena; Tessa, Maria; Rampino, Monica; Ragona, Riccardo; Origlia, Cristina; Del Mastro, Elena; Rotta, Paolo.

In: Radiologia Medica, Vol. 93, No. 6, 06.1997, p. 764-773.

Research output: Contribution to journalArticle

Sacco, M, Tessa, M, Rampino, M, Ragona, R, Origlia, C, Del Mastro, E & Rotta, P 1997, 'Fattori prognostici nel trattamento del carcinoma del collo dell'utero negli stadi IB-IIA: Studio retrospettivo', Radiologia Medica, vol. 93, no. 6, pp. 764-773.
Sacco, Marilena ; Tessa, Maria ; Rampino, Monica ; Ragona, Riccardo ; Origlia, Cristina ; Del Mastro, Elena ; Rotta, Paolo. / Fattori prognostici nel trattamento del carcinoma del collo dell'utero negli stadi IB-IIA : Studio retrospettivo. In: Radiologia Medica. 1997 ; Vol. 93, No. 6. pp. 764-773.
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AU - Ragona, Riccardo

AU - Origlia, Cristina

AU - Del Mastro, Elena

AU - Rotta, Paolo

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