Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database

P. Bertoglio; G. Querzoli; L. Ventura; V. Aprile; M.A. Cattoni; D. Nachira; F. Lococo; M. Rodriguez Perez; F. Guerrera; F. Minervini; L. Gnetti; D. Bacchin; F. Franzi; G. Rindi; S. Bellafiore; F. Femia; A. Viti; G.S. Bogina; P. Kestenholz; E. Ruffini; M. Paci; S. Margaritora; A.S. Imperatori; M. Lucchi; L. Ampollini; A.C. Terzi

doi:10.1002/jso.26292

Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database

P. Bertoglio, G. Querzoli, L. Ventura, V. Aprile, M.A. Cattoni, D. Nachira, F. Lococo, M. Rodriguez Perez, F. Guerrera, F. Minervini, L. Gnetti, D. Bacchin, F. Franzi, G. Rindi, S. Bellafiore, F. Femia, A. Viti, G.S. Bogina, P. Kestenholz, E. RuffiniM. Paci, S. Margaritora, A.S. Imperatori, M. Lucchi, L. Ampollini, A.C. Terzi

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Objectives: Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods: We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria: anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results: Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p =.522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p =.016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p =.005; p =.014; p =.038, respectively) significantly influenced DFS. Conclusions: The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor. © 2020 Wiley Periodicals LLC

Original language	English
Journal	J. Surg. Oncol.
DOIs	https://doi.org/10.1002/jso.26292
Publication status	E-pub ahead of print - Oct 11 2020

Keywords

lung adenocarcinoma
lung cancer biology
lung cancer surgery
non-small-cell lung cancer
aged
Article
body mass
cancer grading
cancer prognosis
cancer staging
cohort analysis
controlled study
disease free survival
European
female
histology
human
lung lobectomy
lymph node dissection
lymph vessel metastasis
major clinical study
male
minimally invasive procedure
minimally invasive surgery
overall survival
priority journal
recurrence risk
retrospective study
segmentectomy
surgical technique
tumor volume
video assisted thoracoscopic surgery

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Bertoglio, P., Querzoli, G., Ventura, L., Aprile, V., Cattoni, M. A., Nachira, D., Lococo, F., Rodriguez Perez, M., Guerrera, F., Minervini, F., Gnetti, L., Bacchin, D., Franzi, F., Rindi, G., Bellafiore, S., Femia, F., Viti, A., Bogina, G. S., Kestenholz, P., ... Terzi, A. C. (2020). Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database. J. Surg. Oncol.. https://doi.org/10.1002/jso.26292

Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database. / Bertoglio, P.; Querzoli, G.; Ventura, L.; Aprile, V.; Cattoni, M.A.; Nachira, D.; Lococo, F.; Rodriguez Perez, M.; Guerrera, F.; Minervini, F.; Gnetti, L.; Bacchin, D.; Franzi, F.; Rindi, G.; Bellafiore, S.; Femia, F.; Viti, A.; Bogina, G.S.; Kestenholz, P.; Ruffini, E.; Paci, M.; Margaritora, S.; Imperatori, A.S.; Lucchi, M.; Ampollini, L.; Terzi, A.C.

In: J. Surg. Oncol., 11.10.2020.

Research output: Contribution to journal › Article › peer-review

Bertoglio, P, Querzoli, G, Ventura, L, Aprile, V, Cattoni, MA, Nachira, D , Lococo, F, Rodriguez Perez, M, Guerrera, F, Minervini, F, Gnetti, L, Bacchin, D, Franzi, F, Rindi, G, Bellafiore, S, Femia, F, Viti, A, Bogina, GS, Kestenholz, P, Ruffini, E, Paci, M , Margaritora, S, Imperatori, AS, Lucchi, M, Ampollini, L & Terzi, AC 2020, 'Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database', J. Surg. Oncol.. https://doi.org/10.1002/jso.26292

Bertoglio, P. ; Querzoli, G. ; Ventura, L. ; Aprile, V. ; Cattoni, M.A. ; Nachira, D. ; Lococo, F. ; Rodriguez Perez, M. ; Guerrera, F. ; Minervini, F. ; Gnetti, L. ; Bacchin, D. ; Franzi, F. ; Rindi, G. ; Bellafiore, S. ; Femia, F. ; Viti, A. ; Bogina, G.S. ; Kestenholz, P. ; Ruffini, E. ; Paci, M. ; Margaritora, S. ; Imperatori, A.S. ; Lucchi, M. ; Ampollini, L. ; Terzi, A.C. / Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database. In: J. Surg. Oncol. 2020.

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title = "Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database",

abstract = "Background and Objectives: Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods: We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria: anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results: Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p =.522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p =.016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p =.005; p =.014; p =.038, respectively) significantly influenced DFS. Conclusions: The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor. {\textcopyright} 2020 Wiley Periodicals LLC",

keywords = "lung adenocarcinoma, lung cancer biology, lung cancer surgery, non-small-cell lung cancer, aged, Article, body mass, cancer grading, cancer prognosis, cancer staging, cohort analysis, controlled study, disease free survival, European, female, histology, human, lung lobectomy, lymph node dissection, lymph vessel metastasis, major clinical study, male, minimally invasive procedure, minimally invasive surgery, overall survival, priority journal, recurrence risk, retrospective study, segmentectomy, surgical technique, tumor volume, video assisted thoracoscopic surgery",

author = "P. Bertoglio and G. Querzoli and L. Ventura and V. Aprile and M.A. Cattoni and D. Nachira and F. Lococo and {Rodriguez Perez}, M. and F. Guerrera and F. Minervini and L. Gnetti and D. Bacchin and F. Franzi and G. Rindi and S. Bellafiore and F. Femia and A. Viti and G.S. Bogina and P. Kestenholz and E. Ruffini and M. Paci and S. Margaritora and A.S. Imperatori and M. Lucchi and L. Ampollini and A.C. Terzi",

note = "Export Date: 24 February 2021 CODEN: JSONA Correspondence Address: Bertoglio, P.; Division of Thoracic Surgery, Italy; email: pieberto@hotmail.com",

year = "2020",

month = oct,

day = "11",

doi = "10.1002/jso.26292",

language = "English",

journal = "J. Surg. Oncol.",

issn = "0022-4790",

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TY - JOUR

T1 - Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database

AU - Bertoglio, P.

AU - Querzoli, G.

AU - Ventura, L.

AU - Aprile, V.

AU - Cattoni, M.A.

AU - Nachira, D.

AU - Lococo, F.

AU - Rodriguez Perez, M.

AU - Guerrera, F.

AU - Minervini, F.

AU - Gnetti, L.

AU - Bacchin, D.

AU - Franzi, F.

AU - Rindi, G.

AU - Bellafiore, S.

AU - Femia, F.

AU - Viti, A.

AU - Bogina, G.S.

AU - Kestenholz, P.

AU - Ruffini, E.

AU - Paci, M.

AU - Margaritora, S.

AU - Imperatori, A.S.

AU - Lucchi, M.

AU - Ampollini, L.

AU - Terzi, A.C.

N1 - Export Date: 24 February 2021 CODEN: JSONA Correspondence Address: Bertoglio, P.; Division of Thoracic Surgery, Italy; email: pieberto@hotmail.com

PY - 2020/10/11

Y1 - 2020/10/11

N2 - Background and Objectives: Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods: We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria: anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results: Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p =.522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p =.016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p =.005; p =.014; p =.038, respectively) significantly influenced DFS. Conclusions: The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor. © 2020 Wiley Periodicals LLC

AB - Background and Objectives: Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods: We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria: anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results: Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p =.522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p =.016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p =.005; p =.014; p =.038, respectively) significantly influenced DFS. Conclusions: The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor. © 2020 Wiley Periodicals LLC

KW - lung adenocarcinoma

KW - lung cancer biology

KW - lung cancer surgery

KW - non-small-cell lung cancer

KW - aged

KW - Article

KW - body mass

KW - cancer grading

KW - cancer prognosis

KW - cancer staging

KW - cohort analysis

KW - controlled study

KW - disease free survival

KW - European

KW - female

KW - histology

KW - human

KW - lung lobectomy

KW - lymph node dissection

KW - lymph vessel metastasis

KW - major clinical study

KW - male

KW - minimally invasive procedure

KW - minimally invasive surgery

KW - overall survival

KW - priority journal

KW - recurrence risk

KW - retrospective study

KW - segmentectomy

KW - surgical technique

KW - tumor volume

KW - video assisted thoracoscopic surgery

U2 - 10.1002/jso.26292

DO - 10.1002/jso.26292

M3 - Article

JO - J. Surg. Oncol.

JF - J. Surg. Oncol.

SN - 0022-4790

ER -