Abstract
Background and Objectives: Adenocarcinoma patterns could be grouped based on clinical behaviors: low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS). Methods: We retrospectively collected data of surgically resected stage I and II adenocarcinoma. Selection criteria: anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas. Results: Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows: lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p =.522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p =.016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p =.005; p =.014; p =.038, respectively) significantly influenced DFS. Conclusions: The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor. © 2020 Wiley Periodicals LLC
Original language | English |
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Journal | J. Surg. Oncol. |
DOIs | |
Publication status | E-pub ahead of print - Oct 11 2020 |
Keywords
- lung adenocarcinoma
- lung cancer biology
- lung cancer surgery
- non-small-cell lung cancer
- aged
- Article
- body mass
- cancer grading
- cancer prognosis
- cancer staging
- cohort analysis
- controlled study
- disease free survival
- European
- female
- histology
- human
- lung lobectomy
- lymph node dissection
- lymph vessel metastasis
- major clinical study
- male
- minimally invasive procedure
- minimally invasive surgery
- overall survival
- priority journal
- recurrence risk
- retrospective study
- segmentectomy
- surgical technique
- tumor volume
- video assisted thoracoscopic surgery