Prognostic Impact of Microsatellite Instability in Asian Gastric Cancer Patients Enrolled in the ARTIST Trial

Rosalba Miceli, Jiyeong An, Maria Di Bartolomeo, Federica Morano, Seung Tae Kim, Se Hoon Park, Min Gew Choi, Joon Ho Lee, Alessandra Raimondi, Giovanni Fucà, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Do Hoon Lim, Won Ki Kang, Kyoung Mee Kim, Filippo Pietrantonio, Jeeyun Lee

Research output: Contribution to journalArticle

Abstract

Background: Caucasian patients with microsatellite instability (MSI)-high gastric cancer (GC) may have better prognosis but worse outcomes. Objective: Here we explored the prognostic role of MSI in Asian patients. Methods: This post hoc analysis comprehended radically resected GC patients randomized to XP (capecitabine/cisplatin) or XPRT. MSI status was assessed by combining immunohistochemistry with multiplex polymerase chain reaction. The MSI prognostic effect on disease-free survival (DFS) and overall survival (OS) was evaluated. Results: 393 tissue samples were analyzed and 35 (9%) were MSI-high. This subgroup was characterized by: older age, Borrmann classification 1-2, antral localization, T3-4 stage, and intestinal type. At univariable analysis, the microsatellite-stable subgroup showed a trend toward a worse prognosis as compared to the MSI-high group: 3-year DFS was 76.3 versus 85.4% (p = 0.122); 3-year OS was 81.7 versus 91.4% (p = 0.046). Multivariable analyses confirmed it in both DFS (hazard ratio, HR = 2.32 [95% CI 0.91, 5.88]; p = 0.077) and OS (HR = 3.17 [95% CI 0.97, 10.43]; p = 0.057). Conclusions: MSI-high status was associated with specific clinical-pathological features and a trend toward better outcomes of Asian GC patients.

Original languageEnglish
Pages (from-to)38-43
Number of pages6
JournalOncology (Switzerland)
Volume97
Issue number1
DOIs
Publication statusPublished - Jul 1 2019

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Keywords

  • Adjuvant therapy
  • Gastric cancer
  • Microsatellite instability
  • Prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Miceli, R., An, J., Di Bartolomeo, M., Morano, F., Kim, S. T., Park, S. H., Choi, M. G., Lee, J. H., Raimondi, A., Fucà, G., Sohn, T. S., Bae, J. M., Kim, S., Lim, D. H., Kang, W. K., Kim, K. M., Pietrantonio, F., & Lee, J. (2019). Prognostic Impact of Microsatellite Instability in Asian Gastric Cancer Patients Enrolled in the ARTIST Trial. Oncology (Switzerland), 97(1), 38-43. https://doi.org/10.1159/000499628