Abstract
AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions.
METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC.
RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients.
CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.
Original language | English |
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Pages (from-to) | 631-643 |
Number of pages | 13 |
Journal | Immunotherapy |
Volume | 11 |
Issue number | 7 |
DOIs | |
Publication status | Published - May 2019 |