Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis

Vincenzo Di Nunno; Veronica Mollica; Lidia Gatto; Matteo Santoni; Laura Cosmai; Camillo Porta; Francesco Massari

doi:10.2217/imt-2018-0175

Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis

Vincenzo Di Nunno, Veronica Mollica, Lidia Gatto, Matteo Santoni, Laura Cosmai, Camillo Porta, Francesco Massari

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article

Abstract

AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions.

METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC.

RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients.

CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.

Original language	English
Pages (from-to)	631-643
Number of pages	13
Journal	Immunotherapy
Volume	11
Issue number	7
DOIs	https://doi.org/10.2217/imt-2018-0175
Publication status	Published - May 2019

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Nunno, V. D., Mollica, V., Gatto, L., Santoni, M., Cosmai, L., Porta, C., & Massari, F. (2019). Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis. Immunotherapy, 11(7), 631-643. https://doi.org/10.2217/imt-2018-0175

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title = "Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis",

abstract = "AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions.METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC.RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients.CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.",

author = "Nunno, {Vincenzo Di} and Veronica Mollica and Lidia Gatto and Matteo Santoni and Laura Cosmai and Camillo Porta and Francesco Massari",

year = "2019",

month = may

doi = "10.2217/imt-2018-0175",

language = "English",

volume = "11",

pages = "631--643",

journal = "Immunotherapy",

issn = "1750-743X",

publisher = "Future Medicine Ltd.",

number = "7",

}

TY - JOUR

T1 - Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma

T2 - a systematic review and meta-analysis

AU - Nunno, Vincenzo Di

AU - Mollica, Veronica

AU - Gatto, Lidia

AU - Santoni, Matteo

AU - Cosmai, Laura

AU - Porta, Camillo

AU - Massari, Francesco

PY - 2019/5

Y1 - 2019/5

N2 - AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions.METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC.RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients.CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.

AB - AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions.METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC.RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients.CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.

U2 - 10.2217/imt-2018-0175

DO - 10.2217/imt-2018-0175

M3 - Article

C2 - 30943858

VL - 11

SP - 631

EP - 643

JO - Immunotherapy

JF - Immunotherapy

SN - 1750-743X

IS - 7

ER -

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Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis

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