Prognostic impact of neutrophil-to-lymphocyte ratio in renal cell carcinoma: a systematic review and meta-analysis

Vincenzo Di Nunno, Veronica Mollica, Lidia Gatto, Matteo Santoni, Laura Cosmai, Camillo Porta, Francesco Massari

Research output: Contribution to journalArticle


AIM: Estimate prognosis and clinical outcome of patients with localized or metastatic renal cell carcinoma (RCC) is an important issue which drive our medical decisions.

METHODS: We carried out a meta-analysis of available clinical studies exploring neutrophil-to-lymphocyte ratio (NLR) in RCC in order to evaluate if this ratio could be correlated to overall survival (OS) and progression-free survival (PFS) of patients with localized/metastatic RCC.

RESULTS: In overall population higher NLR resulted in worst OS and PFS (OS pooled hazard ratio of 1.80; 95% CI: 1.61-2.00; I2 45%; PFS pooled hazard ratio of 1.69; 95% CI: 1.42-2.01; I2 81%), this negative correlation was also confirmed in both metastatic and nonmetastatic patients.

CONCLUSION: The NLR ratio is a variable correlated to prognosis in RCC patients.

Original languageEnglish
Pages (from-to)631-643
Number of pages13
Issue number7
Publication statusPublished - May 2019


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