Prognostic implications of epidermal growth factor receptor immunoreactivity in squamous cell carcinoma of the oral mucosa

Eugenio Maiorano, Gianfranco Favia, Patrick Maisonneuve, Giuseppe Viale

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the clinical significance of the expression of epidermal growth factor receptor (EGFr) in oral squamous cell carcinoma (SCC), 100 formalin-fixed, paraffin-embedded cases of this tumour and ten samples of normal oral mucosa were immunostained with a monoclonal anti-EGFr antibody using an immunoalkaline phosphatase (APAAP) technique. EGFr immunoreactivity was detected in 36 of 100 tumours and in all samples of normal mucosa. Tumour cells demonstrated distinct membrane staining in 14 cases and predominantly cytoplasmic staining in 22 additional cases. EGFr was exclusively localized on the cell membrane of normal epithelial cells. Kaplan-Meyer survival curves and Cox proportional hazard regression models were used to assess overall survival and disease-free survival. A significant positive correlation was shown between EGFr membranous immunoreactivity and prolonged survival, in both univariate and multivariate analyses. Accordingly, patients with oral SCC showing down-regulated expression of membranous EGFr, who are more likely to suffer recurrence and death, should be strictly followed up and possibly treated with more aggressive therapeutic regimens.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalJournal of Pathology
Volume185
Issue number2
DOIs
Publication statusPublished - Jun 1998

Keywords

  • Epidermal growth factor receptor
  • Immunohistochemistry
  • Neoplasm
  • Oral mucosa
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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