Prognostic implications of node metastatic features in OSCC: A retrospective study on 121 neck dissections

Maria Contaldo, Antonio Di Napoli, Giuseppe Pannone, Renato Franco, Franco Ionna, Antonia Feola, Alfredo De Rosa, Angela Santoro, Carolina Sbordone, Francesco Longo, Daniela Pasquali, Carla Loreto, Filippo Ricciardiello, Gennaro Esposito, Luigi D'Angelo, Angelo Itro, Pantaleo Bufo, Vincenzo Tombolini, Rosario Serpico, Marina Di Domenico

Research output: Contribution to journalArticle

Abstract

Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations and contrasts with previous literature. The retrospective study involved 121 patients affected by OSCC who had undergone modified radical ND (MRND) for therapeutic, elective reasons or after intraoperative positivity to metastasis of sentinel lymph nodes (SLN+). Node metastasis frequency and behaviour (typical vs. atypical) and their number and distribution according to pre-surgical cTNM cancer staging were considered and overall survival Kaplan-Meier curves were calculated for each group in order to compare mortality according to ND type (elective, therapeutic, after SLN+), lymph node metastatic pattern (typical or atypical), size (micrometastasis vs. macrometastasis) and number. Results showed statistically significant different overall survival according to pre-surgical staging, number of lymph nodes harvested and intent to surgery. Sentinel lymph node resulted in the sole positive node affected by metastasis in small cT1- cT2/cN0 OSCC and an ND subsequent to its positivity during intraoperative assessment may be considered an overtreatment.

Original languageEnglish
Pages (from-to)2697-2704
Number of pages8
JournalOncology Reports
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 2013

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Keywords

  • Extracapsular spread
  • Lymph node metastasis
  • Micrometastasis
  • Neck dissection
  • Oral cancer
  • Sentinel lymph node
  • Skip metastasis
  • Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Contaldo, M., Di Napoli, A., Pannone, G., Franco, R., Ionna, F., Feola, A., De Rosa, A., Santoro, A., Sbordone, C., Longo, F., Pasquali, D., Loreto, C., Ricciardiello, F., Esposito, G., D'Angelo, L., Itro, A., Bufo, P., Tombolini, V., Serpico, R., & Di Domenico, M. (2013). Prognostic implications of node metastatic features in OSCC: A retrospective study on 121 neck dissections. Oncology Reports, 30(6), 2697-2704. https://doi.org/10.3892/or.2013.2779