Prognostic indicators for early-stage breast carcinoma. Part II: Value of cathepsin d expression, detected by immunocytochemistry. A multiparametric study

P. Bevilacqua, P. Boracchi, G. Gasparini

Research output: Contribution to journalArticlepeer-review

Abstract

Cathepsin D is a lysosomal aspartyl protease which seems to be involved in invasiveness and metastasis in breast carcinoma. Cathepsin D expression detected by immunocytochemistry is a new potentially useful prognostic marker. Additional research is warranted because: (i) few immunocytochemical studies have been performed to correlate cathepsin D expression and prognosis; (ii) a consensus has not yet been achieved on methodology and quality control issues; (iii) the association between cathepsin D expression and other new biological markers is poorly known and (iv) few studies have assessed whether cathepsin D expression is an independent prognostic marker when compared with other biological and clinico-pathological features using multivariate analysis. This study was undertaken in the same series of 165 stage I-II breast cancer patients (median follow-up of 5 years) already reported (Int J Oncol 4: 155-162, 1994) in whom cathepsin D was assessed using the D7E3 monoclonal antibody by immunocytochemistry in frozen specimens, using a standard peroxidaseantiperoxidase complex method. Cathepsin D was compared with another 7 biological markers, as well as with the conventional clinico-pathological features. Forty-two carcinomas of the 165 analyzed (25.5%) were cathepsin D-positive. This marker was significantly associated with c-erB-2 expression (p=0.004) and tumour vascularization (p=0.02). Yet, a weak association was observed between cathepsin D and S-phase fraction (p=0.06). In univariate analysis cathepsin D was significantly associated both with relapse-free survival (p

Original languageEnglish
Pages (from-to)559-564
Number of pages6
JournalInternational Journal of Oncology
Volume5
Issue number3
Publication statusPublished - 1994

Keywords

  • Breast cancer
  • Cathepsin D
  • Immunocytochemistry
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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