Prognostic Indicators in Stage IV Surgically Treated Gastric Cancer Patients: A Retrospective Multi-Institutional Study

Alberto Biondi, Domenico D’Ugo, Ferdinando Cananzi, Stefano Rausei, Federico Sicoli, Francesco Santullo, Antonio Laurino, Laura Ruspi, Francesco Belia, Vittorio Quagliuolo, Roberto Persiani

Research output: Contribution to journalArticle

Abstract

Introduction: The role of gastric resection in treating metastatic gastric adenocarcinoma is controversial. In the present study, we reviewed the short- and long-term outcomes of stage IV patients undergoing surgery. Methods: A retrospective review was conducted that assessed patients undergoing elective surgery for incurable gastric carcinoma. Short- and long-term results were evaluated. Results: A total of 122 stage IV gastric cancer patients were assessed. Postoperative mortality was 5.7%, and the overall rate of complications was 35.2%. The overall survival rate at 1 and 3 years was 58 and 19% respectively; the median survival was 14 months. Improved survival was observed for the factors age less than 60 years (p = 0.015), site of metastases (p = 0.022), extended lymph node dissection (p = 0.044), absence of residual disease after surgery (p = 0.001), and administration of adjuvant chemotherapy (p = 0.016). Multivariate analysis showed that residual disease and adjuvant chemotherapy were independent prognostic factors. Conclusions: The results of this study suggest that surgery combined with systemic chemotherapy in selected patients with stage IV gastric cancer can improve survival.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalDigestive Surgery
DOIs
Publication statusPublished - Jun 26 2018

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Stomach Neoplasms
Stomach
Adjuvant Chemotherapy
Survival
Age Factors
Lymph Node Excision
Adenocarcinoma
Multivariate Analysis
Survival Rate
Neoplasm Metastasis
Carcinoma
Drug Therapy
Mortality

Keywords

  • Advanced stage
  • Gastric cancer
  • Metastatic disease
  • Non-curative gastrectomy

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Prognostic Indicators in Stage IV Surgically Treated Gastric Cancer Patients : A Retrospective Multi-Institutional Study. / Biondi, Alberto; D’Ugo, Domenico; Cananzi, Ferdinando; Rausei, Stefano; Sicoli, Federico; Santullo, Francesco; Laurino, Antonio; Ruspi, Laura; Belia, Francesco; Quagliuolo, Vittorio; Persiani, Roberto.

In: Digestive Surgery, 26.06.2018, p. 1-9.

Research output: Contribution to journalArticle

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abstract = "Introduction: The role of gastric resection in treating metastatic gastric adenocarcinoma is controversial. In the present study, we reviewed the short- and long-term outcomes of stage IV patients undergoing surgery. Methods: A retrospective review was conducted that assessed patients undergoing elective surgery for incurable gastric carcinoma. Short- and long-term results were evaluated. Results: A total of 122 stage IV gastric cancer patients were assessed. Postoperative mortality was 5.7{\%}, and the overall rate of complications was 35.2{\%}. The overall survival rate at 1 and 3 years was 58 and 19{\%} respectively; the median survival was 14 months. Improved survival was observed for the factors age less than 60 years (p = 0.015), site of metastases (p = 0.022), extended lymph node dissection (p = 0.044), absence of residual disease after surgery (p = 0.001), and administration of adjuvant chemotherapy (p = 0.016). Multivariate analysis showed that residual disease and adjuvant chemotherapy were independent prognostic factors. Conclusions: The results of this study suggest that surgery combined with systemic chemotherapy in selected patients with stage IV gastric cancer can improve survival.",
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AU - D’Ugo, Domenico

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AU - Rausei, Stefano

AU - Sicoli, Federico

AU - Santullo, Francesco

AU - Laurino, Antonio

AU - Ruspi, Laura

AU - Belia, Francesco

AU - Quagliuolo, Vittorio

AU - Persiani, Roberto

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AB - Introduction: The role of gastric resection in treating metastatic gastric adenocarcinoma is controversial. In the present study, we reviewed the short- and long-term outcomes of stage IV patients undergoing surgery. Methods: A retrospective review was conducted that assessed patients undergoing elective surgery for incurable gastric carcinoma. Short- and long-term results were evaluated. Results: A total of 122 stage IV gastric cancer patients were assessed. Postoperative mortality was 5.7%, and the overall rate of complications was 35.2%. The overall survival rate at 1 and 3 years was 58 and 19% respectively; the median survival was 14 months. Improved survival was observed for the factors age less than 60 years (p = 0.015), site of metastases (p = 0.022), extended lymph node dissection (p = 0.044), absence of residual disease after surgery (p = 0.001), and administration of adjuvant chemotherapy (p = 0.016). Multivariate analysis showed that residual disease and adjuvant chemotherapy were independent prognostic factors. Conclusions: The results of this study suggest that surgery combined with systemic chemotherapy in selected patients with stage IV gastric cancer can improve survival.

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