Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: Results from IBCSG Trials VIII and IX

Alan S. Coates, Ewan K A Millar, Sandra A. O'Toole, Timothy J. Molloy, Giuseppe Viale, Aron Goldhirsch, Meredith M. Regan, Richard D. Gelber, Zhuoxin Sun, Monica Castiglione-Gertsch, Barry Gusterson, Elizabeth A. Musgrove, Robert L. Sutherland

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Abstract

Introduction: The prognostic significance of p53 protein expression in early breast cancer remains uncertain, with some but not all studies finding an association with poorer outcomes. Estrogen receptor (ER) expression is both a positive prognostic marker and predictive of response to endocrine therapies. The relationship between these biomarkers is unknown.Methods: We constructed tissue microarrays (TMAs) from available pathological material from 1113 patients participating in two randomized clinical trials comparing endocrine therapy alone versus chemo-endocrine therapy in node-negative breast cancer. Expression of p53 defined as >10% positive nuclei was analyzed together with prior immunohistochemical assays of ER performed at central pathological review of whole tumor sections.Results: ER was present (i.e. >1% positive tumor cell nuclei) in 80.1% (880/1092). p53 expression was significantly more frequent when ER was absent, 125/212 (59%) than when ER was present, 171/880 (19%), p

Original languageEnglish
Article numberR143
JournalBreast Cancer Research
Volume14
Issue number6
DOIs
Publication statusPublished - Nov 5 2012

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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    Coates, A. S., Millar, E. K. A., O'Toole, S. A., Molloy, T. J., Viale, G., Goldhirsch, A., Regan, M. M., Gelber, R. D., Sun, Z., Castiglione-Gertsch, M., Gusterson, B., Musgrove, E. A., & Sutherland, R. L. (2012). Prognostic interaction between expression of p53 and estrogen receptor in patients with node-negative breast cancer: Results from IBCSG Trials VIII and IX. Breast Cancer Research, 14(6), [R143]. https://doi.org/10.1186/bcr3348