Prognostic relevance of acute graft-versus-host disease (agvhd) on outcome in patients transplanted with hla-identical sibling transplants for chronic myeloid leukemia (cml) in first chronic phase

A. Gratwohl, R. Brand, J. Apperley, A. V. Biezen, A. Devergie, T. De Witte, F. Frassoni, C. Guglielmi, M. Michallet, H. Kolb, T. Ruutu, D. Niederwieser

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Abstract

Risk assessment remains a challenge for patients with CML. Today, pretransplanl risk factors are well defined and allow targeted approaches. AGvHD was described earlier as post transplant risk factor with reverse effects on transplant related mortality (TRM) and relapse incidence (RI). Minimal or mild aGvHD was shown to have little impact on TRM, hence postulated to have beneficial effects on survival (SURV). This forms the basis for modern low intensity conditioning approaches. We were readressing this issue in a large cohort of patients with CML transplanted in 1st chronic phase from HLAidentical sibling donors. Data from 5761 patients (59% male; 9% l-20y, 59% 20-40y, 32% 40y; 43% <12 months from diagnosis) grafted between 1980 and 1999 and reported to Ihe EBMT database were analysed. 3807 were évaluable for aGvHD. Of these, 42% developed aGvHD. aGvHD N patients TRM RI SURV dlOO(%) 5y(%) 10y() 15y(%) 15y() I5y(

Original languageEnglish
JournalBlood
Volume96
Issue number11 PART I
Publication statusPublished - 2000

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Transplants
Graft vs Host Disease
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Grafts
Siblings
Emitter coupled logic circuits
Mortality
Recurrence
Survival
Incidence
Risk assessment
Tissue Donors
Databases

ASJC Scopus subject areas

  • Hematology

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Prognostic relevance of acute graft-versus-host disease (agvhd) on outcome in patients transplanted with hla-identical sibling transplants for chronic myeloid leukemia (cml) in first chronic phase. / Gratwohl, A.; Brand, R.; Apperley, J.; Biezen, A. V.; Devergie, A.; De Witte, T.; Frassoni, F.; Guglielmi, C.; Michallet, M.; Kolb, H.; Ruutu, T.; Niederwieser, D.

In: Blood, Vol. 96, No. 11 PART I, 2000.

Research output: Contribution to journalArticle

Gratwohl, A, Brand, R, Apperley, J, Biezen, AV, Devergie, A, De Witte, T, Frassoni, F, Guglielmi, C, Michallet, M, Kolb, H, Ruutu, T & Niederwieser, D 2000, 'Prognostic relevance of acute graft-versus-host disease (agvhd) on outcome in patients transplanted with hla-identical sibling transplants for chronic myeloid leukemia (cml) in first chronic phase', Blood, vol. 96, no. 11 PART I.
Gratwohl, A. ; Brand, R. ; Apperley, J. ; Biezen, A. V. ; Devergie, A. ; De Witte, T. ; Frassoni, F. ; Guglielmi, C. ; Michallet, M. ; Kolb, H. ; Ruutu, T. ; Niederwieser, D. / Prognostic relevance of acute graft-versus-host disease (agvhd) on outcome in patients transplanted with hla-identical sibling transplants for chronic myeloid leukemia (cml) in first chronic phase. In: Blood. 2000 ; Vol. 96, No. 11 PART I.
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