Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers

G. Granata; D. Coradini; V. Cappelleti; G. Di Fronzo

doi:10.1016/0277-5379(91)90260-K

Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers

G. Granata, D. Coradini, V. Cappelleti, G. Di Fronzo

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had longer disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.

Original language	English
Pages (from-to)	970-972
Number of pages	3
Journal	European Journal of Cancer and Clinical Oncology
Volume	27
Issue number	8
DOIs	https://doi.org/10.1016/0277-5379(91)90260-K
Publication status	Published - 1991

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1016/0277-5379(91)90260-K

Fingerprint Dive into the research topics of 'Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers'. Together they form a unique fingerprint.

Cite this

@article{1e8894cf4fda48b89f12811595caea70,

title = "Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers",

abstract = "The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had longer disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.",

author = "G. Granata and D. Coradini and V. Cappelleti and {Di Fronzo}, G.",

year = "1991",

doi = "10.1016/0277-5379(91)90260-K",

language = "English",

volume = "27",

pages = "970--972",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd",

number = "8",

}

TY - JOUR

T1 - Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers

AU - Granata, G.

AU - Coradini, D.

AU - Cappelleti, V.

AU - Di Fronzo, G.

PY - 1991

Y1 - 1991

N2 - The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had longer disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.

AB - The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had longer disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=0025887793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025887793&partnerID=8YFLogxK

U2 - 10.1016/0277-5379(91)90260-K

DO - 10.1016/0277-5379(91)90260-K

M3 - Article

C2 - 1832905

AN - SCOPUS:0025887793

VL - 27

SP - 970

EP - 972

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 8

ER -