Prognostic relevance of CCN3 in bone sarcomas

Bernard Perbal, Noureddine Lazar, Diana Zambelli, Monia Zuntini, Massimo Serra, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Piero Picci, Katia Scotlandi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Osteosarcomas and Ewing's sarcoma (EWS) are aggressive malignant bone tumors. In both cases, prognostic markers are lacking. Presently, only clinical features are widely accepted as prognostic indicators. In this study we assessed the prognostic value of CCN3 (Nov), a matricellular protein that belong to the CCN family of regulatory proteins, whose members were shown to play crucial roles in bone formation. In osteosarcomas, CCN3 expression levels represent a useful tool to early identification of patients with different prognosis. In both osteosarcomas and Ewing's sarcomas, the expression of a full length CCN3 protein was associated to a worse prognostic and a higher risk to developing metastasis. In Ewing's tumors, the expression of a CCN3 protein lacking the internal VWC module was associated with reduced tumorigenic potential and better outcome.

Original languageEnglish
Title of host publicationCCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes
PublisherSpringer Netherlands
Pages223-243
Number of pages21
ISBN (Print)9789048137787
DOIs
Publication statusPublished - 2010

Fingerprint

Nephroblastoma Overexpressed Protein
Ewing's Sarcoma
Osteosarcoma
Sarcoma
Bone and Bones
CCN Intercellular Signaling Proteins
Osteogenesis
Neoplasm Metastasis
Neoplasms
Proteins

Keywords

  • CCN3
  • Ewing's sarcoma
  • Matrix Prognostic
  • Osteosarcoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Perbal, B., Lazar, N., Zambelli, D., Zuntini, M., Serra, M., Lopez-Guerrero, J. A., ... Scotlandi, K. (2010). Prognostic relevance of CCN3 in bone sarcomas. In CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes (pp. 223-243). Springer Netherlands. https://doi.org/10.1007/978-90-481-3779-4_17

Prognostic relevance of CCN3 in bone sarcomas. / Perbal, Bernard; Lazar, Noureddine; Zambelli, Diana; Zuntini, Monia; Serra, Massimo; Lopez-Guerrero, Jose Antonio; Llombart-Bosch, Antonio; Picci, Piero; Scotlandi, Katia.

CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes. Springer Netherlands, 2010. p. 223-243.

Research output: Chapter in Book/Report/Conference proceedingChapter

Perbal, B, Lazar, N, Zambelli, D, Zuntini, M, Serra, M, Lopez-Guerrero, JA, Llombart-Bosch, A, Picci, P & Scotlandi, K 2010, Prognostic relevance of CCN3 in bone sarcomas. in CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes. Springer Netherlands, pp. 223-243. https://doi.org/10.1007/978-90-481-3779-4_17
Perbal B, Lazar N, Zambelli D, Zuntini M, Serra M, Lopez-Guerrero JA et al. Prognostic relevance of CCN3 in bone sarcomas. In CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes. Springer Netherlands. 2010. p. 223-243 https://doi.org/10.1007/978-90-481-3779-4_17
Perbal, Bernard ; Lazar, Noureddine ; Zambelli, Diana ; Zuntini, Monia ; Serra, Massimo ; Lopez-Guerrero, Jose Antonio ; Llombart-Bosch, Antonio ; Picci, Piero ; Scotlandi, Katia. / Prognostic relevance of CCN3 in bone sarcomas. CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes. Springer Netherlands, 2010. pp. 223-243
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