Osteosarcomas and Ewing's sarcoma (EWS) are aggressive malignant bone tumors. In both cases, prognostic markers are lacking. Presently, only clinical features are widely accepted as prognostic indicators. In this study we assessed the prognostic value of CCN3 (Nov), a matricellular protein that belong to the CCN family of regulatory proteins, whose members were shown to play crucial roles in bone formation. In osteosarcomas, CCN3 expression levels represent a useful tool to early identification of patients with different prognosis. In both osteosarcomas and Ewing's sarcomas, the expression of a full length CCN3 protein was associated to a worse prognostic and a higher risk to developing metastasis. In Ewing's tumors, the expression of a CCN3 protein lacking the internal VWC module was associated with reduced tumorigenic potential and better outcome.
|Title of host publication||CCN Proteins in Health and Disease: An Overview of the Fifth International Workshop on the CCN Family of Genes|
|Number of pages||21|
|Publication status||Published - 2010|
- Ewing's sarcoma
- Matrix Prognostic
ASJC Scopus subject areas