TY - JOUR
T1 - Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes
AU - Lambertenghi-Deliliers, G.
AU - Annaloro, C.
AU - Oriani, A.
AU - Soligo, D.
AU - Pozzoli, E.
AU - Polli, E. E.
PY - 1993/2
Y1 - 1993/2
N2 - Bone marrow biopsy (BMB) has aroused growing interest as a possible aid in the diagnostic and prognostic evaluation of myelodysplastic syndromes (MDS). Previous reports have pointed out that MDS patients with blastic aggregates or severe bone marrow (BM) fibrosis are characterized by a worse clinical outcome. BMBs of 106 MDS patients were retrospectively reviewed, and relationships among the different histological parameters as well as clinicopathological correlations were looked for. Three patterns of BM blastic infiltration ("diffuse," "cluster," and "large") were recognized. Overt leukemic transformation and overall survival were selected as prognostic end points. BM infiltration was "diffuse" in 18, "cluster" in 48, and "large" in 40 cases. RAEB-t patients accounted for about half of the "large" cases, and none had a "diffuse" pattern (p
AB - Bone marrow biopsy (BMB) has aroused growing interest as a possible aid in the diagnostic and prognostic evaluation of myelodysplastic syndromes (MDS). Previous reports have pointed out that MDS patients with blastic aggregates or severe bone marrow (BM) fibrosis are characterized by a worse clinical outcome. BMBs of 106 MDS patients were retrospectively reviewed, and relationships among the different histological parameters as well as clinicopathological correlations were looked for. Three patterns of BM blastic infiltration ("diffuse," "cluster," and "large") were recognized. Overt leukemic transformation and overall survival were selected as prognostic end points. BM infiltration was "diffuse" in 18, "cluster" in 48, and "large" in 40 cases. RAEB-t patients accounted for about half of the "large" cases, and none had a "diffuse" pattern (p
KW - Bone marrow biopsy
KW - FAB
KW - Myelodysplastic syndromes
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U2 - 10.1007/BF01695890
DO - 10.1007/BF01695890
M3 - Article
C2 - 8448244
AN - SCOPUS:0027410882
VL - 66
SP - 85
EP - 91
JO - Revue d'hématologie
JF - Revue d'hématologie
SN - 0939-5555
IS - 2
ER -