Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes

G. Lambertenghi-Deliliers; C. Annaloro; A. Oriani; D. Soligo; E. Pozzoli; E. E. Polli

doi:10.1007/BF01695890

Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes

G. Lambertenghi-Deliliers, C. Annaloro, A. Oriani, D. Soligo, E. Pozzoli, E. E. Polli

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

Bone marrow biopsy (BMB) has aroused growing interest as a possible aid in the diagnostic and prognostic evaluation of myelodysplastic syndromes (MDS). Previous reports have pointed out that MDS patients with blastic aggregates or severe bone marrow (BM) fibrosis are characterized by a worse clinical outcome. BMBs of 106 MDS patients were retrospectively reviewed, and relationships among the different histological parameters as well as clinicopathological correlations were looked for. Three patterns of BM blastic infiltration ("diffuse," "cluster," and "large") were recognized. Overt leukemic transformation and overall survival were selected as prognostic end points. BM infiltration was "diffuse" in 18, "cluster" in 48, and "large" in 40 cases. RAEB-t patients accounted for about half of the "large" cases, and none had a "diffuse" pattern (p

Original language	English
Pages (from-to)	85-91
Number of pages	7
Journal	Annals of Hematology
Volume	66
Issue number	2
DOIs	https://doi.org/10.1007/BF01695890
Publication status	Published - Feb 1993

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Keywords

Bone marrow biopsy
FAB
Myelodysplastic syndromes

ASJC Scopus subject areas

Hematology

Cite this

Lambertenghi-Deliliers, G., Annaloro, C., Oriani, A., Soligo, D., Pozzoli, E., & Polli, E. E. (1993). Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes. Annals of Hematology, 66(2), 85-91. https://doi.org/10.1007/BF01695890

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10.1007/BF01695890