Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes

G. Lambertenghi-Deliliers, C. Annaloro, A. Oriani, D. Soligo, E. Pozzoli, E. E. Polli

Research output: Contribution to journalArticle

Abstract

Bone marrow biopsy (BMB) has aroused growing interest as a possible aid in the diagnostic and prognostic evaluation of myelodysplastic syndromes (MDS). Previous reports have pointed out that MDS patients with blastic aggregates or severe bone marrow (BM) fibrosis are characterized by a worse clinical outcome. BMBs of 106 MDS patients were retrospectively reviewed, and relationships among the different histological parameters as well as clinicopathological correlations were looked for. Three patterns of BM blastic infiltration ("diffuse," "cluster," and "large") were recognized. Overt leukemic transformation and overall survival were selected as prognostic end points. BM infiltration was "diffuse" in 18, "cluster" in 48, and "large" in 40 cases. RAEB-t patients accounted for about half of the "large" cases, and none had a "diffuse" pattern (p

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalAnnals of Hematology
Volume66
Issue number2
DOIs
Publication statusPublished - Feb 1993

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Keywords

  • Bone marrow biopsy
  • FAB
  • Myelodysplastic syndromes

ASJC Scopus subject areas

  • Hematology

Cite this

Lambertenghi-Deliliers, G., Annaloro, C., Oriani, A., Soligo, D., Pozzoli, E., & Polli, E. E. (1993). Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes. Annals of Hematology, 66(2), 85-91. https://doi.org/10.1007/BF01695890