TY - JOUR
T1 - Prognostic relevance of serum thymidine kinase in primary myelodysplastic syndromes
T2 - Relationship to development of acute myeloid leukaemia
AU - Musto, P.
AU - Bodenizza, C.
AU - Falcone, A.
AU - D'Arena, G.
AU - Scalzulli, P.
AU - Perla, G.
AU - Modoni, S.
AU - Parlatore, L.
AU - Valvano, M. R.
AU - Carotenuto, M.
PY - 1995
Y1 - 1995
N2 - The aim of this study was to evaluate the possible prognostic relevance of thymidine kinase serum levels (s-TK), an indirect marker of proliferative activity, in myelodysplastic syndromes (MDS). S-TK levels were monitored by means of a radioenzyme assay in 90 patients affected by MDS (22 refractory anaemia, RA; 17 RA with ring sideroblasts, RARS; 21 RA with blast excess, RAEB; 15 RAEB in transformation, RAEB-T; 15 chronic myelomonocytic leukaemia, CMMoL). Mean s-TK levels (U/μl) measured at diagnosis were 11.9 ± 12.6 for RA, 11.4 ± 13.6 for RARS, 19.9 ± 28.4 for RAEB, 39.6 ± 34.3 for RAEB-T and 77.7 ± 69.7 for CMMoL (normal values 38 U/μl, a cut-off level selected by means of ROC statistical analysis, showed a significantly shorter survival than those with s-TK 38 U/μl and 9/69 (13%) of those with lower levels at diagnosis (P <0.0001), independently of FAB subtype. High s-TK levels were also useful to predict evolution in AML during the course of the disease in patients with normal initial values. Multivariate analysis confirmed the independent prognostic value of s-TK on both overall survival and risk of acute transformation. We conclude that s-TK may be an important prognostic factor in MDS, strongly correlated with development of AML.
AB - The aim of this study was to evaluate the possible prognostic relevance of thymidine kinase serum levels (s-TK), an indirect marker of proliferative activity, in myelodysplastic syndromes (MDS). S-TK levels were monitored by means of a radioenzyme assay in 90 patients affected by MDS (22 refractory anaemia, RA; 17 RA with ring sideroblasts, RARS; 21 RA with blast excess, RAEB; 15 RAEB in transformation, RAEB-T; 15 chronic myelomonocytic leukaemia, CMMoL). Mean s-TK levels (U/μl) measured at diagnosis were 11.9 ± 12.6 for RA, 11.4 ± 13.6 for RARS, 19.9 ± 28.4 for RAEB, 39.6 ± 34.3 for RAEB-T and 77.7 ± 69.7 for CMMoL (normal values 38 U/μl, a cut-off level selected by means of ROC statistical analysis, showed a significantly shorter survival than those with s-TK 38 U/μl and 9/69 (13%) of those with lower levels at diagnosis (P <0.0001), independently of FAB subtype. High s-TK levels were also useful to predict evolution in AML during the course of the disease in patients with normal initial values. Multivariate analysis confirmed the independent prognostic value of s-TK on both overall survival and risk of acute transformation. We conclude that s-TK may be an important prognostic factor in MDS, strongly correlated with development of AML.
KW - Acute leukaemias
KW - Myerodysplastic syndromes
KW - Prognostic factors
KW - Thymidine kinase
UR - http://www.scopus.com/inward/record.url?scp=0029046926&partnerID=8YFLogxK
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M3 - Article
C2 - 7786774
AN - SCOPUS:0029046926
VL - 90
SP - 125
EP - 130
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -