Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast

Vincenzo Eusebi, Maria G. Cattani, Janez Lamovec, Davide Treré, Claudio Ceccarelli, Paolo Veronesi, Claudio Clemente, Massimo Derenzini

Research output: Contribution to journalArticlepeer-review

Abstract

Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.

Original languageEnglish
Pages (from-to)203-214
Number of pages12
JournalUltrastructural Pathology
Volume15
Issue number3
DOIs
Publication statusPublished - 1991

Keywords

  • Breast
  • Nucleolar organizer regions
  • Prognosis
  • Sarcomatoid carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

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