Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast

Vincenzo Eusebi, Maria G. Cattani, Janez Lamovec, Davide Treré, Claudio Ceccarelli, Paolo Veronesi, Claudio Clemente, Massimo Derenzini

Research output: Contribution to journalArticle

Abstract

Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.

Original languageEnglish
Pages (from-to)203-214
Number of pages12
JournalUltrastructural Pathology
Volume15
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Nuclear Proteins
Silver
breast
cancer
silver
Breast Neoplasms
proteins
Proteins
Nucleolus Organizer Region
analyzers
Coloring Agents

Keywords

  • Breast
  • Nucleolar organizer regions
  • Prognosis
  • Sarcomatoid carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology
  • Instrumentation

Cite this

Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast. / Eusebi, Vincenzo; Cattani, Maria G.; Lamovec, Janez; Treré, Davide; Ceccarelli, Claudio; Veronesi, Paolo; Clemente, Claudio; Derenzini, Massimo.

In: Ultrastructural Pathology, Vol. 15, No. 3, 1991, p. 203-214.

Research output: Contribution to journalArticle

Eusebi, V, Cattani, MG, Lamovec, J, Treré, D, Ceccarelli, C, Veronesi, P, Clemente, C & Derenzini, M 1991, 'Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast', Ultrastructural Pathology, vol. 15, no. 3, pp. 203-214. https://doi.org/10.3109/01913129109021882
Eusebi, Vincenzo ; Cattani, Maria G. ; Lamovec, Janez ; Treré, Davide ; Ceccarelli, Claudio ; Veronesi, Paolo ; Clemente, Claudio ; Derenzini, Massimo. / Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast. In: Ultrastructural Pathology. 1991 ; Vol. 15, No. 3. pp. 203-214.
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