Prognostic risk stratification derived from individual patient level data for men with advanced penile squamous cell carcinoma receiving first-line systemic therapy

Gregory R. Pond, Giuseppe Di Lorenzo, Andrea Necchi, Bernhard J. Eigl, Michael P. Kolinsky, Raju T. Chacko, Tanya B. Dorff, Lauren C. Harshman, Matthew I. Milowsky, Richard J. Lee, Matthew D. Galsky, Piera Federico, Graeme Bolger, Mollie DeShazo, Amitkumar Mehta, Jatinder Goyal, Guru Sonpavde

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prognostic factors in men with penile squamous cell carcinoma (PSCC) receiving systemic therapy are unknown. A prognostic classification system in this disease may facilitate interpretation of outcomes and guide rational drug development. We performed a retrospective analysis to identify prognostic factors in men with PSCC receiving first-line systemic therapy for advanced disease. Patients and methods: Individual patient level data were obtained from 13 institutions to study prognostic factors in the context of first-line systemic therapy for advanced PSCC. Cox proportional hazards regression analysis was conducted to examine the prognostic effect of these candidate factors on progression-free survival (PFS) and overall survival (OS): age, stage, hemoglobin, neutrophil count, lymphocyte count, albumin, site of metastasis (visceral or nonvisceral), smoking, circumcision, regimen, ECOG performance status (PS), lymphovascular invasion, precancerous lesion, and surgery following chemotherapy. The effect of different treatments was then evaluated adjusting for factors in the prognostic model. Results: The study included 140 eligible men. Mean age across all men was 57.0 years. Among them, 8.6%, 21.4%, and 70.0% of patients had stage 2, 3, and 4 diseases, respectively; 40.7% had ECOG PS≥1, 47.4% had visceral metastases, and 73.6% received cisplatin-based chemotherapy. The multivariate model of poor prognostic factors included visceral metastases (P

Original languageEnglish
Pages (from-to)501-508
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume32
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Advanced
  • Penile squamous cell carcinoma
  • Prognosis
  • Systemic therapy

ASJC Scopus subject areas

  • Oncology
  • Urology

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