Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials

Gennaro Daniele; Laura Arenare; Giovanni Scambia; Carmela Pisano; Roberto Sorio; Enrico Breda; Sabino De Placido; Antonella Savarese; Gabriella Ferrandina; Francesco Raspagliesi; Pierluigi Benedetti Panici; Antonella Ferro; Anita Rimanti; Gennaro Cormio; Domenica Lorusso; Sabrina Chiara Cecere; Simona Scalone; Valentina Angela Marsico; Cinzia Cardalesi; Francesco Cognetti; Vanda Salutari; Laura Attademo; Lorenzo Guizzaro; Clorinda Schettino; Maria Carmela Piccirillo; Francesco Perrone; Ciro Gallo; Sandro Pignata

doi:10.1016/j.ygyno.2019.04.012

Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials

Gennaro Daniele, Laura Arenare, Giovanni Scambia, Carmela Pisano, Roberto Sorio, Enrico Breda, Sabino De Placido, Antonella Savarese, Gabriella Ferrandina, Francesco Raspagliesi, Pierluigi Benedetti Panici, Antonella Ferro, Anita Rimanti, Gennaro Cormio, Domenica Lorusso, Sabrina Chiara Cecere, Simona Scalone, Valentina Angela Marsico, Cinzia Cardalesi, Francesco CognettiVanda Salutari, Laura Attademo, Lorenzo Guizzaro, Clorinda Schettino, Maria Carmela Piccirillo, Francesco Perrone, Ciro Gallo, Sandro Pignata

Research output: Contribution to journal › Article › peer-review

Abstract

Chemotherapy-induced neutropenia (CIN) has been associated with improved prognosis in several cancer conditions. Contrasting data have been produced in ovarian cancer.

Original language	English
Pages (from-to)	83-88
Number of pages	6
Journal	Gynecologic Oncology
Volume	154
Issue number	1
DOIs	https://doi.org/10.1016/j.ygyno.2019.04.012
Publication status	Published - Jul 2019

Keywords

*Chemotherapy-induced neutropenia
*Cytotoxic dosing methods
*Meta-analysis
*Ovarian cancer
*Prognostic factors
*Retrospective-prospective design
Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use
Carboplatin/administration & dosage/adverse effects
Doxorubicin/administration & dosage/adverse effects/analogs & derivatives
Female
Humans
Kaplan-Meier Estimate
Middle Aged
Neoplasm Staging
Neutropenia/*chemically induced
Ovarian Neoplasms/*blood/*drug therapy/pathology
Paclitaxel/administration & dosage/adverse effects
Polyethylene Glycols/administration & dosage/adverse effects
Prognosis
Progression-Free Survival
Prospective Studies
Retrospective Studies

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10.1016/j.ygyno.2019.04.012

https://pubmed.ncbi.nlm.nih.gov/31029508

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Daniele, G., Arenare, L., Scambia, G., Pisano, C., Sorio, R., Breda, E., De Placido, S., Savarese, A., Ferrandina, G., Raspagliesi, F., Panici, P. B., Ferro, A., Rimanti, A., Cormio, G., Lorusso, D., Cecere, S. C., Scalone, S., Marsico, V. A., Cardalesi, C., ... Pignata, S. (2019). Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials. Gynecologic Oncology, 154(1), 83-88. https://doi.org/10.1016/j.ygyno.2019.04.012

Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials. / Daniele, Gennaro ; Arenare, Laura ; Scambia, Giovanni ; Pisano, Carmela ; Sorio, Roberto; Breda, Enrico; De Placido, Sabino; Savarese, Antonella; Ferrandina, Gabriella; Raspagliesi, Francesco; Panici, Pierluigi Benedetti; Ferro, Antonella; Rimanti, Anita; Cormio, Gennaro; Lorusso, Domenica ; Cecere, Sabrina Chiara ; Scalone, Simona; Marsico, Valentina Angela; Cardalesi, Cinzia; Cognetti, Francesco ; Salutari, Vanda ; Attademo, Laura; Guizzaro, Lorenzo; Schettino, Clorinda ; Piccirillo, Maria Carmela ; Perrone, Francesco; Gallo, Ciro; Pignata, Sandro.

In: Gynecologic Oncology, Vol. 154, No. 1, 07.2019, p. 83-88.

Research output: Contribution to journal › Article › peer-review

Daniele, G , Arenare, L , Scambia, G , Pisano, C , Sorio, R, Breda, E, De Placido, S, Savarese, A, Ferrandina, G, Raspagliesi, F, Panici, PB, Ferro, A, Rimanti, A, Cormio, G, Lorusso, D , Cecere, SC , Scalone, S, Marsico, VA, Cardalesi, C, Cognetti, F , Salutari, V , Attademo, L, Guizzaro, L, Schettino, C , Piccirillo, MC , Perrone, F, Gallo, C & Pignata, S 2019, 'Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials', Gynecologic Oncology, vol. 154, no. 1, pp. 83-88. https://doi.org/10.1016/j.ygyno.2019.04.012

Daniele, Gennaro ; Arenare, Laura ; Scambia, Giovanni ; Pisano, Carmela ; Sorio, Roberto ; Breda, Enrico ; De Placido, Sabino ; Savarese, Antonella ; Ferrandina, Gabriella ; Raspagliesi, Francesco ; Panici, Pierluigi Benedetti ; Ferro, Antonella ; Rimanti, Anita ; Cormio, Gennaro ; Lorusso, Domenica ; Cecere, Sabrina Chiara ; Scalone, Simona ; Marsico, Valentina Angela ; Cardalesi, Cinzia ; Cognetti, Francesco ; Salutari, Vanda ; Attademo, Laura ; Guizzaro, Lorenzo ; Schettino, Clorinda ; Piccirillo, Maria Carmela ; Perrone, Francesco ; Gallo, Ciro ; Pignata, Sandro. / Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials. In: Gynecologic Oncology. 2019 ; Vol. 154, No. 1. pp. 83-88.

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title = "Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials",

abstract = "Chemotherapy-induced neutropenia (CIN) has been associated with improved prognosis in several cancer conditions. Contrasting data have been produced in ovarian cancer.",

keywords = "*Chemotherapy-induced neutropenia, *Cytotoxic dosing methods, *Meta-analysis, *Ovarian cancer, *Prognostic factors, *Retrospective-prospective design, Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use, Carboplatin/administration & dosage/adverse effects, Doxorubicin/administration & dosage/adverse effects/analogs & derivatives, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Neoplasm Staging, Neutropenia/*chemically induced, Ovarian Neoplasms/*blood/*drug therapy/pathology, Paclitaxel/administration & dosage/adverse effects, Polyethylene Glycols/administration & dosage/adverse effects, Prognosis, Progression-Free Survival, Prospective Studies, Retrospective Studies",

author = "Gennaro Daniele and Laura Arenare and Giovanni Scambia and Carmela Pisano and Roberto Sorio and Enrico Breda and {De Placido}, Sabino and Antonella Savarese and Gabriella Ferrandina and Francesco Raspagliesi and Panici, {Pierluigi Benedetti} and Antonella Ferro and Anita Rimanti and Gennaro Cormio and Domenica Lorusso and Cecere, {Sabrina Chiara} and Simona Scalone and Marsico, {Valentina Angela} and Cinzia Cardalesi and Francesco Cognetti and Vanda Salutari and Laura Attademo and Lorenzo Guizzaro and Clorinda Schettino and Piccirillo, {Maria Carmela} and Francesco Perrone and Ciro Gallo and Sandro Pignata",

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AU - Pisano, Carmela

AU - Sorio, Roberto

AU - Breda, Enrico

AU - De Placido, Sabino

AU - Savarese, Antonella

AU - Ferrandina, Gabriella

AU - Raspagliesi, Francesco

AU - Panici, Pierluigi Benedetti

AU - Ferro, Antonella

AU - Rimanti, Anita

AU - Cormio, Gennaro

AU - Lorusso, Domenica

AU - Cecere, Sabrina Chiara

AU - Scalone, Simona

AU - Marsico, Valentina Angela

AU - Cardalesi, Cinzia

AU - Cognetti, Francesco

AU - Salutari, Vanda

AU - Attademo, Laura

AU - Guizzaro, Lorenzo

AU - Schettino, Clorinda

AU - Piccirillo, Maria Carmela

AU - Perrone, Francesco

AU - Gallo, Ciro

AU - Pignata, Sandro

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KW - Neoplasm Staging

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KW - Progression-Free Survival

KW - Prospective Studies

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DO - 10.1016/j.ygyno.2019.04.012

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JF - Gynecologic Oncology

SN - 0090-8258

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ER -

Prognostic role of chemotherapy-induced neutropenia in first-line treatment of advanced ovarian cancer. A pooled analysis of MITO2 and MITO7 trials

Abstract

Keywords

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