@article{91c73558f24d4577ba0e2f93426faa77,
title = "Prognostic role of FDG PET/CT in patients with differentiated thyroid cancer treated with 131-iodine empiric therapy",
abstract = "Background: To assess the long-term prognostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with differentiated thyroid carcinoma (DTC) undergoing empiric radioiodine (RAI) therapy due to raising values of thyroglobulin (Tg). Methods: Forty-nine patients with histological diagnosis of DTC (31 with papillary and 18 with follicular carcinoma) follow-up for a mean period of 7.9±5 years after empiric RAI therapy were retrospectively analyzed. Results:FDG-PET/CT was negative in 15 (30.6%) patients and positive in 34 (69.4%), whereas postradioiodine therapy whole body scan (t-WBS) was negative in 16 (32.7%) and positive in 33 (67.3%) patients. FDG-PET/CT and t-WBS were in agreement in 32 patients (7 both negative and 25 both positive); on the contrary, in 17 patients there was disagreement between FDG-PET/CT and t-WBS (P=ns). At short-term follow-up, Tg normalized in 19 (38.8%) patients and was unchanged or increased in 30 (61.2%). Of the 15 patients with negative FDG-PET/CT, 11 (73.3%) showed Tg normalization, whereas of the 34 patients with positive FDG-PET/CT, only 8 (23.5%) had Tg normalization (x2=8.9, P<.005). At multivariate analysis, FDG-PET/CT and Tg normalization at short-term follow-up were independent predictors of disease-free survival (x2=26.3, P<.0001), while Tg normalization was the only variable associated with overall survival x2=7.2, P<.01). Conclusion: FDG-PET/CT in association with Tg normalization at short-term follow-up may be useful for long-term prognostic stratification in DTC patients.. {\textcopyright} 2017 the Author(s). Published by Wolters Kluwer Health, Inc.",
keywords = "18F-FDG-PET/CT, differentiated thyroid carcinoma, empiric therapy, prognosis, thyroglobulin, fluorodeoxyglucose f 18, iodine 131, radioactive iodine, radiopharmaceutical agent, adult, Article, cancer diagnosis, cancer patient, cancer prognosis, cancer survival, clinical article, differentiated thyroid cancer, disease free survival, female, follow up, histopathology, human, male, medical record review, middle aged, overall survival, positron emission tomography-computed tomography, priority journal, retrospective study, thyroglobulin blood level, thyroid follicular carcinoma, thyroid papillary carcinoma, whole body scintiscanning, aged, biosynthesis, diagnostic imaging, mortality, pathology, Thyroid Neoplasms, Adult, Aged, Disease-Free Survival, Female, Fluorodeoxyglucose F18, Humans, Iodine Radioisotopes, Male, Middle Aged, Positron Emission Tomography Computed Tomography, Prognosis, Radiopharmaceuticals, Retrospective Studies, Thyroglobulin",
author = "B. Salvatore and M. Klain and E. Nicolai and D. D'Amico and {De Matteis}, G. and M. Raddi and R. Fonti and T. Pellegrino and G. Storto and A. Cuocolo and L. Pace",
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year = "2017",
month = oct
doi = "10.1097/MD.0000000000008344",
language = "English",
volume = "96",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "42",
}