Prognostic role of primary tumor, nodal neck, and retropharyngeal GTVs for unresectable sinonasal cancers treated with IMRT and chemotherapy.

Letizia Ferella, Anna Cavallo, Rosalba Miceli, Nicola Alessandro Iacovelli, Tommaso Giandini, Emanuele Pignoli, Giuseppina Calareso, Paolo Bossi, Carlo Resteghini, Giovanni Luca Gravina, Piero Nicolai, Paolo Castelnuovo, Cesare Piazza, Lisa Licitra, Carlo Fallai, Ester Orlandi

Research output: Contribution to journalArticlepeer-review


BACKGROUND: We evaluated the prognostic role of gross tumor volumes (GTVs) of primary tumor and positive lymph nodes on overall survival (OS) and progression-free survival (PFS) in locally advanced unresectable sinonasal cancer (SNC) treated with definitive intensity-modulated radiotherapy (IMRT) with or without chemotherapy. METHODS: Primary tumor GTV (GTV-T), pathologic neck nodes GTV (GTV-N), and positive retropharyngeal nodes GTV (GTV-RPN) of 34 patients with epithelial nonglandular SNC receiving IMRT with or without chemotherapy were retrospectively measured. The GTV variables were analyzed in relation with OS and PFS. Survival curves were estimated using the Kaplan-Meier method and compared with the log-rank test. We also estimated the crude cumulative incidence of locoregional relapses only. The optimal volume cutoff value was determined using an outcome-oriented method among the observed values. RESULTS: GTV-T was significantly associated with decreased OS (P=0.003) and PFS (P=0.003). Moreover, patients with disease total volumes (GTV) smaller than 149.44 cm³ had better OS and PFS than patients with higher volumes (P
Original languageEnglish
Pages (from-to)39-46
Number of pages8
Issue number1
Publication statusPublished - 2020


  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • chemotherapy
  • prognostic factors
  • Combined Modality Therapy
  • Neoplasm Staging
  • Aged
  • Lymphatic Metastasis
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Aged, 80 and over
  • Tumor Burden
  • Treatment Outcome
  • Radiotherapy Dosage
  • Radiometry
  • Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
  • Gross tumor volume
  • IMRT
  • Paranasal Sinus Neoplasms/*mortality/*pathology/therapy
  • Pharyngeal Neoplasms/*mortality/*pathology/therapy
  • Radiotherapy, Intensity-Modulated/adverse effects/methods
  • sinonasal cancer


Dive into the research topics of 'Prognostic role of primary tumor, nodal neck, and retropharyngeal GTVs for unresectable sinonasal cancers treated with IMRT and chemotherapy.'. Together they form a unique fingerprint.

Cite this