Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients

Massimo Iacoviello, P. Guida, E. Guastamacchia, V. Triggiani, C. Forleo, R. Catanzaro, M. Cicala, M. Basile, S. Sorrentino, S. Favale

Research output: Contribution to journalArticlepeer-review


Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients with cardiovascular disease. Aim. To evaluate the prognostic role of thyroid function deficiency in patients with chronic heart failure (CHF). Methods. We evaluated 338 consecutive outpatients with stable CHF receiving conventional therapy, all of whom underwent a physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, and Na+, hemoglobin, NT-proBNPs, fT3, fT4 and TSH levels. Patients with hyperthyroidism were excluded. Results. During the follow-up (15±8 months), heart failure progression was observed in 79 patients (including 18 who died of heart failure after hospitalisation and six who underwent transplantation). Univariate regression analysis showed that TSH (p5.5 mUI/l; p=0.014) remained significantly associated with the events. Conclusions. In CHF patients TSH levels even slightly above normal range are independently associated with a greater likelihood of heart failure progression. This supports the need for prospective studies aimed at clarifying the most appropriate therapeutic approach to sub-clinical hypothyroidism in such patients.

Original languageEnglish
Pages (from-to)2686-2692
Number of pages7
JournalCurrent Pharmaceutical Design
Issue number26
Publication statusPublished - 2008


  • Chronic heart failure
  • Prognosis
  • Sub-clinical hypothyroidism
  • Thyroid hormones

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology


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