Abstract
Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients with cardiovascular disease. Aim. To evaluate the prognostic role of thyroid function deficiency in patients with chronic heart failure (CHF). Methods. We evaluated 338 consecutive outpatients with stable CHF receiving conventional therapy, all of whom underwent a physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, and Na+, hemoglobin, NT-proBNPs, fT3, fT4 and TSH levels. Patients with hyperthyroidism were excluded. Results. During the follow-up (15±8 months), heart failure progression was observed in 79 patients (including 18 who died of heart failure after hospitalisation and six who underwent transplantation). Univariate regression analysis showed that TSH (p5.5 mUI/l; p=0.014) remained significantly associated with the events. Conclusions. In CHF patients TSH levels even slightly above normal range are independently associated with a greater likelihood of heart failure progression. This supports the need for prospective studies aimed at clarifying the most appropriate therapeutic approach to sub-clinical hypothyroidism in such patients.
| Original language | English |
|---|---|
| Pages (from-to) | 2686-2692 |
| Number of pages | 7 |
| Journal | Current Pharmaceutical Design |
| Volume | 14 |
| Issue number | 26 |
| DOIs | |
| Publication status | Published - 2008 |
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Keywords
- Chronic heart failure
- Prognosis
- Sub-clinical hypothyroidism
- Thyroid hormones
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
Cite this
Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients. / Iacoviello, Massimo; Guida, P.; Guastamacchia, E.; Triggiani, V.; Forleo, C.; Catanzaro, R.; Cicala, M.; Basile, M.; Sorrentino, S.; Favale, S.
In: Current Pharmaceutical Design, Vol. 14, No. 26, 2008, p. 2686-2692.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients
AU - Iacoviello, Massimo
AU - Guida, P.
AU - Guastamacchia, E.
AU - Triggiani, V.
AU - Forleo, C.
AU - Catanzaro, R.
AU - Cicala, M.
AU - Basile, M.
AU - Sorrentino, S.
AU - Favale, S.
PY - 2008
Y1 - 2008
N2 - Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients with cardiovascular disease. Aim. To evaluate the prognostic role of thyroid function deficiency in patients with chronic heart failure (CHF). Methods. We evaluated 338 consecutive outpatients with stable CHF receiving conventional therapy, all of whom underwent a physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, and Na+, hemoglobin, NT-proBNPs, fT3, fT4 and TSH levels. Patients with hyperthyroidism were excluded. Results. During the follow-up (15±8 months), heart failure progression was observed in 79 patients (including 18 who died of heart failure after hospitalisation and six who underwent transplantation). Univariate regression analysis showed that TSH (p5.5 mUI/l; p=0.014) remained significantly associated with the events. Conclusions. In CHF patients TSH levels even slightly above normal range are independently associated with a greater likelihood of heart failure progression. This supports the need for prospective studies aimed at clarifying the most appropriate therapeutic approach to sub-clinical hypothyroidism in such patients.
AB - Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients with cardiovascular disease. Aim. To evaluate the prognostic role of thyroid function deficiency in patients with chronic heart failure (CHF). Methods. We evaluated 338 consecutive outpatients with stable CHF receiving conventional therapy, all of whom underwent a physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, and Na+, hemoglobin, NT-proBNPs, fT3, fT4 and TSH levels. Patients with hyperthyroidism were excluded. Results. During the follow-up (15±8 months), heart failure progression was observed in 79 patients (including 18 who died of heart failure after hospitalisation and six who underwent transplantation). Univariate regression analysis showed that TSH (p5.5 mUI/l; p=0.014) remained significantly associated with the events. Conclusions. In CHF patients TSH levels even slightly above normal range are independently associated with a greater likelihood of heart failure progression. This supports the need for prospective studies aimed at clarifying the most appropriate therapeutic approach to sub-clinical hypothyroidism in such patients.
KW - Chronic heart failure
KW - Prognosis
KW - Sub-clinical hypothyroidism
KW - Thyroid hormones
UR - http://www.scopus.com/inward/record.url?scp=57349145932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57349145932&partnerID=8YFLogxK
U2 - 10.2174/138161208786264142
DO - 10.2174/138161208786264142
M3 - Article
C2 - 19006851
AN - SCOPUS:57349145932
VL - 14
SP - 2686
EP - 2692
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
SN - 1381-6128
IS - 26
ER -