Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients

Massimo Iacoviello, P. Guida, E. Guastamacchia, V. Triggiani, C. Forleo, R. Catanzaro, M. Cicala, M. Basile, S. Sorrentino, S. Favale

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients with cardiovascular disease. Aim. To evaluate the prognostic role of thyroid function deficiency in patients with chronic heart failure (CHF). Methods. We evaluated 338 consecutive outpatients with stable CHF receiving conventional therapy, all of whom underwent a physical examination, electrocardiography and echocardiography. Blood samples were drawn to assess renal function, and Na+, hemoglobin, NT-proBNPs, fT3, fT4 and TSH levels. Patients with hyperthyroidism were excluded. Results. During the follow-up (15±8 months), heart failure progression was observed in 79 patients (including 18 who died of heart failure after hospitalisation and six who underwent transplantation). Univariate regression analysis showed that TSH (p5.5 mUI/l; p=0.014) remained significantly associated with the events. Conclusions. In CHF patients TSH levels even slightly above normal range are independently associated with a greater likelihood of heart failure progression. This supports the need for prospective studies aimed at clarifying the most appropriate therapeutic approach to sub-clinical hypothyroidism in such patients.

Original languageEnglish
Pages (from-to)2686-2692
Number of pages7
JournalCurrent Pharmaceutical Design
Volume14
Issue number26
DOIs
Publication statusPublished - 2008

Fingerprint

Hypothyroidism
Outpatients
Heart Failure
Hyperthyroidism
Thyroid Hormones
Physical Examination
Echocardiography
Thyroid Gland
Electrocardiography
Reference Values
Hemoglobins
Hospitalization
Cardiovascular Diseases
Transplantation
Regression Analysis
Prospective Studies
Kidney
Mortality
Therapeutics

Keywords

  • Chronic heart failure
  • Prognosis
  • Sub-clinical hypothyroidism
  • Thyroid hormones

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Iacoviello, M., Guida, P., Guastamacchia, E., Triggiani, V., Forleo, C., Catanzaro, R., ... Favale, S. (2008). Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients. Current Pharmaceutical Design, 14(26), 2686-2692. https://doi.org/10.2174/138161208786264142

Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients. / Iacoviello, Massimo; Guida, P.; Guastamacchia, E.; Triggiani, V.; Forleo, C.; Catanzaro, R.; Cicala, M.; Basile, M.; Sorrentino, S.; Favale, S.

In: Current Pharmaceutical Design, Vol. 14, No. 26, 2008, p. 2686-2692.

Research output: Contribution to journalArticle

Iacoviello, M, Guida, P, Guastamacchia, E, Triggiani, V, Forleo, C, Catanzaro, R, Cicala, M, Basile, M, Sorrentino, S & Favale, S 2008, 'Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients', Current Pharmaceutical Design, vol. 14, no. 26, pp. 2686-2692. https://doi.org/10.2174/138161208786264142
Iacoviello M, Guida P, Guastamacchia E, Triggiani V, Forleo C, Catanzaro R et al. Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients. Current Pharmaceutical Design. 2008;14(26):2686-2692. https://doi.org/10.2174/138161208786264142
Iacoviello, Massimo ; Guida, P. ; Guastamacchia, E. ; Triggiani, V. ; Forleo, C. ; Catanzaro, R. ; Cicala, M. ; Basile, M. ; Sorrentino, S. ; Favale, S. / Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients. In: Current Pharmaceutical Design. 2008 ; Vol. 14, No. 26. pp. 2686-2692.
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