Prognostic significance of arterial phase CT for prediction of response to transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma: A retrospective analysis

S. Katyal, J. H. Oliver, M. S. Peterson, P. J. Chang, R. L. Baron, B. I. Carr

Research output: Contribution to journalArticle

Abstract

OBJECTIYE. The purpose of this study was to use hepatic arterial phase helical CT to assess tumor vascularity and predict the likelihood of response to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. MATERIALS AND METHODS. Helical CT findings for 57 patients with hepatocellular carcinoma were classified into one of three patterns of vascularity on the basis of the degree of tumor or liver enhancement during the hepatic arterial phase. Cases in which hypervascular lesions predominated were classified as a type 1 pattern. Cases in which hypovascular lesions predominated were classified as a type 2 pattern. Patients were classified as responders or nonresponders on the basis of the changes of tumor size revealed on CT after three transcatheter arterial chemoembolization treatments. RESULTS. We classified the 57 patients as 37 responders (65%) and 20 nonresponders (35%). A statistically significant correlation between the type 1 hypervascular pattern and response to transcatheter arterial chemoembolization was seen; conversely, the type 2 hypovascular pattern correlated with nonresponse to transcatheter arterial chemoembolization (chi-square = 7.85, p = 0.02). Patients classified as responders lived significantly longer than those classified as nonresponders with 12-, 24-, and 36-month survival rates of 90%, 67%, and 36%, respectively, for responders and 70%, 17%, and 10%, respectively, for nonresponders. CONCLUSION. We found that patients who responded to transcatheter arterial chemoembolization had prolonged survival (p <0.01). Response correlated closely with tumor vascularity as shown on hepatic arterial phase helical CT.

Original languageEnglish
Pages (from-to)1665-1672
Number of pages8
JournalAmerican Journal of Roentgenology
Volume175
Issue number6
Publication statusPublished - 2000

Fingerprint

Hepatocellular Carcinoma
Spiral Computed Tomography
Liver
Neoplasms
Survival Rate
Survival
Therapeutics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Prognostic significance of arterial phase CT for prediction of response to transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma : A retrospective analysis. / Katyal, S.; Oliver, J. H.; Peterson, M. S.; Chang, P. J.; Baron, R. L.; Carr, B. I.

In: American Journal of Roentgenology, Vol. 175, No. 6, 2000, p. 1665-1672.

Research output: Contribution to journalArticle

@article{b2fe6fd451c94475a11b19254e6c091e,
title = "Prognostic significance of arterial phase CT for prediction of response to transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma: A retrospective analysis",
abstract = "OBJECTIYE. The purpose of this study was to use hepatic arterial phase helical CT to assess tumor vascularity and predict the likelihood of response to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. MATERIALS AND METHODS. Helical CT findings for 57 patients with hepatocellular carcinoma were classified into one of three patterns of vascularity on the basis of the degree of tumor or liver enhancement during the hepatic arterial phase. Cases in which hypervascular lesions predominated were classified as a type 1 pattern. Cases in which hypovascular lesions predominated were classified as a type 2 pattern. Patients were classified as responders or nonresponders on the basis of the changes of tumor size revealed on CT after three transcatheter arterial chemoembolization treatments. RESULTS. We classified the 57 patients as 37 responders (65{\%}) and 20 nonresponders (35{\%}). A statistically significant correlation between the type 1 hypervascular pattern and response to transcatheter arterial chemoembolization was seen; conversely, the type 2 hypovascular pattern correlated with nonresponse to transcatheter arterial chemoembolization (chi-square = 7.85, p = 0.02). Patients classified as responders lived significantly longer than those classified as nonresponders with 12-, 24-, and 36-month survival rates of 90{\%}, 67{\%}, and 36{\%}, respectively, for responders and 70{\%}, 17{\%}, and 10{\%}, respectively, for nonresponders. CONCLUSION. We found that patients who responded to transcatheter arterial chemoembolization had prolonged survival (p <0.01). Response correlated closely with tumor vascularity as shown on hepatic arterial phase helical CT.",
author = "S. Katyal and Oliver, {J. H.} and Peterson, {M. S.} and Chang, {P. J.} and Baron, {R. L.} and Carr, {B. I.}",
year = "2000",
language = "English",
volume = "175",
pages = "1665--1672",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "6",

}

TY - JOUR

T1 - Prognostic significance of arterial phase CT for prediction of response to transcatheter arterial chemoembolization in unresectable hepatocellular carcinoma

T2 - A retrospective analysis

AU - Katyal, S.

AU - Oliver, J. H.

AU - Peterson, M. S.

AU - Chang, P. J.

AU - Baron, R. L.

AU - Carr, B. I.

PY - 2000

Y1 - 2000

N2 - OBJECTIYE. The purpose of this study was to use hepatic arterial phase helical CT to assess tumor vascularity and predict the likelihood of response to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. MATERIALS AND METHODS. Helical CT findings for 57 patients with hepatocellular carcinoma were classified into one of three patterns of vascularity on the basis of the degree of tumor or liver enhancement during the hepatic arterial phase. Cases in which hypervascular lesions predominated were classified as a type 1 pattern. Cases in which hypovascular lesions predominated were classified as a type 2 pattern. Patients were classified as responders or nonresponders on the basis of the changes of tumor size revealed on CT after three transcatheter arterial chemoembolization treatments. RESULTS. We classified the 57 patients as 37 responders (65%) and 20 nonresponders (35%). A statistically significant correlation between the type 1 hypervascular pattern and response to transcatheter arterial chemoembolization was seen; conversely, the type 2 hypovascular pattern correlated with nonresponse to transcatheter arterial chemoembolization (chi-square = 7.85, p = 0.02). Patients classified as responders lived significantly longer than those classified as nonresponders with 12-, 24-, and 36-month survival rates of 90%, 67%, and 36%, respectively, for responders and 70%, 17%, and 10%, respectively, for nonresponders. CONCLUSION. We found that patients who responded to transcatheter arterial chemoembolization had prolonged survival (p <0.01). Response correlated closely with tumor vascularity as shown on hepatic arterial phase helical CT.

AB - OBJECTIYE. The purpose of this study was to use hepatic arterial phase helical CT to assess tumor vascularity and predict the likelihood of response to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. MATERIALS AND METHODS. Helical CT findings for 57 patients with hepatocellular carcinoma were classified into one of three patterns of vascularity on the basis of the degree of tumor or liver enhancement during the hepatic arterial phase. Cases in which hypervascular lesions predominated were classified as a type 1 pattern. Cases in which hypovascular lesions predominated were classified as a type 2 pattern. Patients were classified as responders or nonresponders on the basis of the changes of tumor size revealed on CT after three transcatheter arterial chemoembolization treatments. RESULTS. We classified the 57 patients as 37 responders (65%) and 20 nonresponders (35%). A statistically significant correlation between the type 1 hypervascular pattern and response to transcatheter arterial chemoembolization was seen; conversely, the type 2 hypovascular pattern correlated with nonresponse to transcatheter arterial chemoembolization (chi-square = 7.85, p = 0.02). Patients classified as responders lived significantly longer than those classified as nonresponders with 12-, 24-, and 36-month survival rates of 90%, 67%, and 36%, respectively, for responders and 70%, 17%, and 10%, respectively, for nonresponders. CONCLUSION. We found that patients who responded to transcatheter arterial chemoembolization had prolonged survival (p <0.01). Response correlated closely with tumor vascularity as shown on hepatic arterial phase helical CT.

UR - http://www.scopus.com/inward/record.url?scp=0033647333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033647333&partnerID=8YFLogxK

M3 - Article

C2 - 11090401

AN - SCOPUS:0033647333

VL - 175

SP - 1665

EP - 1672

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

IS - 6

ER -