Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction

M. Angelillis, C. Giannini, M. De Carlo, M. Adamo, M. Nardi, A. Colombo, A. Chieffo, F. Bedogni, N. Brambilla, C. Tamburino, M. Barbanti, G. Bruschi, P. Colombo, A. Poli, P. Martina, R. Violini, P. Presbitero, A.S. Petronio

Research output: Contribution to journalArticle

Abstract

Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis compared with patients with preserved LVEF. To evaluate the impact of early LVEF recovery in patients with baseline dysfunction on clinical outcomes after transcatheter aortic valve implantation (TAVI), we included all consecutive patients who underwent TAVI from the Italian ClinicalService registry with an LVEF of ≤45% at baseline who had 1-month LVEF data. Patients who experienced a previous coronary artery bypass graft, a previous valve replacement, or a previous myocardial infarction were excluded from the analysis. Therefore, 131 patients with an improvement in LVEF of
Original languageEnglish
Pages (from-to)1639-1647
Number of pages9
JournalAmerican Journal of Cardiology
Volume120
Issue number9
DOIs
Publication statusPublished - 2017

Fingerprint

Aortic Valve Stenosis
Left Ventricular Dysfunction
Stroke Volume
Coronary Artery Bypass
Registries
Transcatheter Aortic Valve Replacement
Myocardial Infarction
Transplants

Keywords

  • acetylsalicylic acid
  • bivalirudin
  • clopidogrel
  • heparin
  • aged
  • anticoagulant therapy
  • aortic valve stenosis
  • Article
  • cardiovascular mortality
  • cardiovascular parameters
  • controlled study
  • disease registry
  • disease severity
  • drug safety
  • female
  • heart left ventricle ejection fraction
  • heart left ventricle failure
  • high risk patient
  • hospital discharge
  • human
  • major clinical study
  • male
  • percutaneous coronary intervention
  • priority journal
  • prognostic assessment
  • survival rate
  • transcatheter aortic valve implantation
  • treatment outcome
  • treatment response
  • very elderly
  • complication
  • convalescence
  • heart left ventricle function
  • heart stroke volume
  • mortality
  • pathophysiology
  • physiology
  • prognosis
  • retrospective study
  • Aged
  • Aged, 80 and over
  • Aortic Valve Stenosis
  • Female
  • Humans
  • Male
  • Prognosis
  • Recovery of Function
  • Retrospective Studies
  • Stroke Volume
  • Transcatheter Aortic Valve Replacement
  • Treatment Outcome
  • Ventricular Dysfunction, Left

Cite this

Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction. / Angelillis, M.; Giannini, C.; De Carlo, M.; Adamo, M.; Nardi, M.; Colombo, A.; Chieffo, A.; Bedogni, F.; Brambilla, N.; Tamburino, C.; Barbanti, M.; Bruschi, G.; Colombo, P.; Poli, A.; Martina, P.; Violini, R.; Presbitero, P.; Petronio, A.S.

In: American Journal of Cardiology, Vol. 120, No. 9, 2017, p. 1639-1647.

Research output: Contribution to journalArticle

Angelillis, M. ; Giannini, C. ; De Carlo, M. ; Adamo, M. ; Nardi, M. ; Colombo, A. ; Chieffo, A. ; Bedogni, F. ; Brambilla, N. ; Tamburino, C. ; Barbanti, M. ; Bruschi, G. ; Colombo, P. ; Poli, A. ; Martina, P. ; Violini, R. ; Presbitero, P. ; Petronio, A.S. / Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction. In: American Journal of Cardiology. 2017 ; Vol. 120, No. 9. pp. 1639-1647.
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title = "Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction",
abstract = "Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis compared with patients with preserved LVEF. To evaluate the impact of early LVEF recovery in patients with baseline dysfunction on clinical outcomes after transcatheter aortic valve implantation (TAVI), we included all consecutive patients who underwent TAVI from the Italian ClinicalService registry with an LVEF of ≤45{\%} at baseline who had 1-month LVEF data. Patients who experienced a previous coronary artery bypass graft, a previous valve replacement, or a previous myocardial infarction were excluded from the analysis. Therefore, 131 patients with an improvement in LVEF of",
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author = "M. Angelillis and C. Giannini and {De Carlo}, M. and M. Adamo and M. Nardi and A. Colombo and A. Chieffo and F. Bedogni and N. Brambilla and C. Tamburino and M. Barbanti and G. Bruschi and P. Colombo and A. Poli and P. Martina and R. Violini and P. Presbitero and A.S. Petronio",
note = "Export Date: 2 March 2018 CODEN: AJCDA Correspondence Address: Angelillis, M.; Cardio-Thoracic Department, Azienda Ospedaliero-Universitaria PisanaItaly; email: angelillismarco@gmail.com Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; bivalirudin, 128270-60-0, 1191386-50-1; clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5 Funding details: Edwards Lifesciences Funding details: Medtronic Funding details: Abbott Fund Funding text: C. Tamburino had received speaker honoraria from Abbott, Medtronic, Stentys, and Bionsensor. M. Barbanti is a consultant for Edwards Lifesciences. G. Bruschi is a consultant for Medtronic and St. Jude-Abbott. A.S. Petronio is a consultant for Medtronic. All the other authors have no conflict of interest to declare. References: Fraccaro, C., Al-Lamee, R., Tarantini, G., Maisano, F., Napodano, M., Montorfano, M., Frigo, A.C., Colombo, A., Transcatheter aortic valve implantation in patients with severe left ventricular dysfunction: immediate and mid-term results, a multicenter study (2012) Circ Cardiovasc Interv, 5, pp. 253-260; Passeri, J.J., Elmariah, S., Xu, K., Inglessis, I., Baker, J.N., Alu, M., Kodali, S., Douglas, P.S., Transcatheter aortic valve replacement and standard therapy in inoperable patients with aortic stenosis and low EF (2015) Heart, 101, pp. 463-471; Baron, S.J., Arnold, S.V., Herrmann, H.C., Holmes, D.R., Szeto, W.Y., Allen, K.B., Chhatriwalla, A.K., Cohen, D.J., Impact of ejection fraction and aortic valve gradient on outcomes of transcatheter aortic valve replacement (2016) J Am Coll Cardiol, 67, pp. 2349-2358; Dauerman, H.L., Reardon, M.J., Popma, J.J., Little, S.H., Cavalcante, J.L., Adams, D.H., Kleiman, N.S., Oh, J.K., Early recovery of left ventricular systolic function after CoreValve transcatheter aortic valve replacement (2016) Circ Cardiovasc Interv, 9; Elmariah, S., Palacios, I.F., McAndrew, T., Hueter, I., Inglessis, I., Baker, J.N., Kodali, S., Passeri, J.J., Outcomes of transcatheter and surgical aortic valve replacement in high-risk patients with aortic stenosis and left ventricular dysfunction: results from the Placement of Aortic Transcatheter Valves (PARTNER) trial (cohort A) (2013) Circ Cardiovasc Interv, 6, pp. 604-614; Ussia, G.P., Barbanti, M., Petronio, A.S., Tarantini, G., Ettori, F., Colombo, A., Violini, R., Tamburino, C., Transcatheter aortic valve implantation: 3-year outcomes of self-expanding CoreValve prosthesis (2012) Eur Heart J, 33, pp. 969-976; Tamburino, C., Capodanno, D., Ramondo, A., Petronio, A.S., Ettori, F., Santoro, G., Klugmann, S., Ussia, G.P., Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis (2011) Circulation, 123, pp. 299-308; Barbash, I.M., Minha, S., Ben-Dor, I., Dvir, D., Magalhaes, M.A., Torguson, R., Okubagzi, P., Waksman, R., Relation of preprocedural assessment of myocardial contractility reserve on outcomes of aortic stenosis patients with impaired left ventricular function undergoing transcatheter aortic valve implantation (2014) Am J Cardiol, 113, pp. 1536-1542; Erez, A., Segev, A., Medvedofsky, D., Fefer, P., Raanani, E., Goldenberg, I., Guetta, V., Factors affecting survival in men versus women following transcatheter aortic valve implantation (2014) Am J Cardiol, 113, pp. 701-705; Masson, J.B., Lee, M., Boone, R.H., Al Ali, A., Al Bugami, S., Hamburger, J., John Mancini, G.B., Webb, J.G., Impact of coronary artery disease on outcomes after transcatheter aortic valve implantation (2010) Catheter Cardiovasc Interv, 76, pp. 165-173; Luo, X., Zhao, Z., Chai, H., Zhang, C., Liao, Y., Li, Q., Peng, Y., Huang, D., Efficacy of transcatheter aortic valve implantation in patients with aortic stenosis and reduced LVEF. A systematic review (2015) Herz, 40, pp. 168-180; Quere, J.P., Monin, J.L., Levy, F., Petit, H., Baleynaud, S., Chauvel, C., Pop, C., Tribouilloy, C., Influence of preoperative left ventricular contractile reserve on postoperative ejection fraction in low-gradient aortic stenosis (2006) Circulation, 113, pp. 1738-1744; Petronio, A.S., Giannini, C., De Carlo, M., Bedogni, F., Colombo, A., Tamburino, C., Klugmann, S., Ettori, F., Anaesthetic management of transcatheter aortic valve implantation: results from the Italian CoreValve registry (2016) EuroIntervention, 12, pp. 381-388; Covello, R.D., Ruggeri, L., Landoni, G., Guarracino, F., Bignami, E., Gonfalini, M., Virzo, I., Zangrillo, A., Transcatheter implantation of an aortic valve: anesthesiological management (2010) Minerva Anestesiol, 76, pp. 100-108; Kappetein, A.P., Head, S.J., G{\'e}n{\'e}reux, P., Piazza, N., van Mieghem, N.M., Blackstone, E.H., Brott, T.G., Leon, M.B., Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (2012) J Am Coll Cardiol, 60, pp. 1438-1454; Connolly, H.M., Oh, J.K., Orszulak, T.A., Osborn, S.L., Roger, V.L., Hodge, D.O., Bailey, K.R., Tajik, A.J., Aortic valve replacement for aortic stenosis with severe left ventricular dysfunction. Prognostic indicators (1997) Circulation, 95, pp. 2395-2400; Tarantini, G., Buja, P., Scognamiglio, R., Razzolini, R., Gerosa, G., Isabella, G., Ramondo, A., Iliceto, S., Aortic valve replacement in severe aortic stenosis with left ventricular dysfunction: determinants of cardiac mortality and ventricular function recovery (2003) Eur J Cardiothorac Surg, 24, pp. 879-885; Morris, J.J., Schaff, H.V., Mullany, C.J., Rastogi, A., McGregor, C.G., Daly, R.C., Frye, R.L., Orszulak, T.A., Determinants of survival and recovery of left ventricular function after aortic valve replacement (1993) Ann Thorac Surg, 56, pp. 22-29. , discussion 29–30; Goncalves, A., Marcos-Alberca, P., Almeria, C., Feltes, G., Rodriguez, E., Hernandez-Antolin, R.A., Garcia, E., Zamorano, J.L., Acute left ventricle diastolic function improvement after transcatheter aortic valve implantation (2011) Eur J Echocardiogr, 12, pp. 790-797; Giannini, C., Petronio, A.S., Nardi, C., De Carlo, M., Guarracino, F., Delle Donne, M.G., Talini, E., Di Bello, V., Left ventricular reverse remodeling in percutaneous and surgical aortic bioprostheses: an echocardiographic study (2010) J Am Soc Echocardiogr, 24, pp. 28-36; Clavel, M.A., Webb, J.G., Rodes-Cabau, J., Masson, J.B., Dumont, E., De Larochelliere, R., Doyle, D., Pibarot, P., Comparison between transcatheter and surgical prosthetic valve implantation in patients with severe aortic stenosis and reduced left ventricular ejection fraction (2010) Circulation, 122, pp. 1928-1936; Berland, J., Cribier, A., Savin, T., Lefebvre, E., Koning, R., Letac, B., Percutaneous balloon valvuloplasty in patients with severe aortic stenosis and low ejection fraction. Immediate results and 1-year follow-up (1989) Circulation, 79, pp. 1189-1196; Bonow, R.O., Rosing, D.R., Maron, B.J., McIntosh, C.L., Jones, M., Bacharach, S.L., Green, M.V., Epstein, S.E., Reversal of left ventricular dysfunction after aortic valve replacement for chronic aortic regurgitation: influence of duration of preoperative left ventricular dysfunction (1984) Circulation, 70, pp. 570-579",
year = "2017",
doi = "10.1016/j.amjcard.2017.07.064",
language = "English",
volume = "120",
pages = "1639--1647",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction

AU - Angelillis, M.

AU - Giannini, C.

AU - De Carlo, M.

AU - Adamo, M.

AU - Nardi, M.

AU - Colombo, A.

AU - Chieffo, A.

AU - Bedogni, F.

AU - Brambilla, N.

AU - Tamburino, C.

AU - Barbanti, M.

AU - Bruschi, G.

AU - Colombo, P.

AU - Poli, A.

AU - Martina, P.

AU - Violini, R.

AU - Presbitero, P.

AU - Petronio, A.S.

N1 - Export Date: 2 March 2018 CODEN: AJCDA Correspondence Address: Angelillis, M.; Cardio-Thoracic Department, Azienda Ospedaliero-Universitaria PisanaItaly; email: angelillismarco@gmail.com Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; bivalirudin, 128270-60-0, 1191386-50-1; clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8; heparin, 37187-54-5, 8057-48-5, 8065-01-8, 9005-48-5 Funding details: Edwards Lifesciences Funding details: Medtronic Funding details: Abbott Fund Funding text: C. Tamburino had received speaker honoraria from Abbott, Medtronic, Stentys, and Bionsensor. M. Barbanti is a consultant for Edwards Lifesciences. G. Bruschi is a consultant for Medtronic and St. Jude-Abbott. A.S. Petronio is a consultant for Medtronic. All the other authors have no conflict of interest to declare. References: Fraccaro, C., Al-Lamee, R., Tarantini, G., Maisano, F., Napodano, M., Montorfano, M., Frigo, A.C., Colombo, A., Transcatheter aortic valve implantation in patients with severe left ventricular dysfunction: immediate and mid-term results, a multicenter study (2012) Circ Cardiovasc Interv, 5, pp. 253-260; Passeri, J.J., Elmariah, S., Xu, K., Inglessis, I., Baker, J.N., Alu, M., Kodali, S., Douglas, P.S., Transcatheter aortic valve replacement and standard therapy in inoperable patients with aortic stenosis and low EF (2015) Heart, 101, pp. 463-471; Baron, S.J., Arnold, S.V., Herrmann, H.C., Holmes, D.R., Szeto, W.Y., Allen, K.B., Chhatriwalla, A.K., Cohen, D.J., Impact of ejection fraction and aortic valve gradient on outcomes of transcatheter aortic valve replacement (2016) J Am Coll Cardiol, 67, pp. 2349-2358; Dauerman, H.L., Reardon, M.J., Popma, J.J., Little, S.H., Cavalcante, J.L., Adams, D.H., Kleiman, N.S., Oh, J.K., Early recovery of left ventricular systolic function after CoreValve transcatheter aortic valve replacement (2016) Circ Cardiovasc Interv, 9; Elmariah, S., Palacios, I.F., McAndrew, T., Hueter, I., Inglessis, I., Baker, J.N., Kodali, S., Passeri, J.J., Outcomes of transcatheter and surgical aortic valve replacement in high-risk patients with aortic stenosis and left ventricular dysfunction: results from the Placement of Aortic Transcatheter Valves (PARTNER) trial (cohort A) (2013) Circ Cardiovasc Interv, 6, pp. 604-614; Ussia, G.P., Barbanti, M., Petronio, A.S., Tarantini, G., Ettori, F., Colombo, A., Violini, R., Tamburino, C., Transcatheter aortic valve implantation: 3-year outcomes of self-expanding CoreValve prosthesis (2012) Eur Heart J, 33, pp. 969-976; Tamburino, C., Capodanno, D., Ramondo, A., Petronio, A.S., Ettori, F., Santoro, G., Klugmann, S., Ussia, G.P., Incidence and predictors of early and late mortality after transcatheter aortic valve implantation in 663 patients with severe aortic stenosis (2011) Circulation, 123, pp. 299-308; Barbash, I.M., Minha, S., Ben-Dor, I., Dvir, D., Magalhaes, M.A., Torguson, R., Okubagzi, P., Waksman, R., Relation of preprocedural assessment of myocardial contractility reserve on outcomes of aortic stenosis patients with impaired left ventricular function undergoing transcatheter aortic valve implantation (2014) Am J Cardiol, 113, pp. 1536-1542; Erez, A., Segev, A., Medvedofsky, D., Fefer, P., Raanani, E., Goldenberg, I., Guetta, V., Factors affecting survival in men versus women following transcatheter aortic valve implantation (2014) Am J Cardiol, 113, pp. 701-705; Masson, J.B., Lee, M., Boone, R.H., Al Ali, A., Al Bugami, S., Hamburger, J., John Mancini, G.B., Webb, J.G., Impact of coronary artery disease on outcomes after transcatheter aortic valve implantation (2010) Catheter Cardiovasc Interv, 76, pp. 165-173; Luo, X., Zhao, Z., Chai, H., Zhang, C., Liao, Y., Li, Q., Peng, Y., Huang, D., Efficacy of transcatheter aortic valve implantation in patients with aortic stenosis and reduced LVEF. A systematic review (2015) Herz, 40, pp. 168-180; Quere, J.P., Monin, J.L., Levy, F., Petit, H., Baleynaud, S., Chauvel, C., Pop, C., Tribouilloy, C., Influence of preoperative left ventricular contractile reserve on postoperative ejection fraction in low-gradient aortic stenosis (2006) Circulation, 113, pp. 1738-1744; Petronio, A.S., Giannini, C., De Carlo, M., Bedogni, F., Colombo, A., Tamburino, C., Klugmann, S., Ettori, F., Anaesthetic management of transcatheter aortic valve implantation: results from the Italian CoreValve registry (2016) EuroIntervention, 12, pp. 381-388; Covello, R.D., Ruggeri, L., Landoni, G., Guarracino, F., Bignami, E., Gonfalini, M., Virzo, I., Zangrillo, A., Transcatheter implantation of an aortic valve: anesthesiological management (2010) Minerva Anestesiol, 76, pp. 100-108; Kappetein, A.P., Head, S.J., Généreux, P., Piazza, N., van Mieghem, N.M., Blackstone, E.H., Brott, T.G., Leon, M.B., Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document (2012) J Am Coll Cardiol, 60, pp. 1438-1454; Connolly, H.M., Oh, J.K., Orszulak, T.A., Osborn, S.L., Roger, V.L., Hodge, D.O., Bailey, K.R., Tajik, A.J., Aortic valve replacement for aortic stenosis with severe left ventricular dysfunction. Prognostic indicators (1997) Circulation, 95, pp. 2395-2400; Tarantini, G., Buja, P., Scognamiglio, R., Razzolini, R., Gerosa, G., Isabella, G., Ramondo, A., Iliceto, S., Aortic valve replacement in severe aortic stenosis with left ventricular dysfunction: determinants of cardiac mortality and ventricular function recovery (2003) Eur J Cardiothorac Surg, 24, pp. 879-885; Morris, J.J., Schaff, H.V., Mullany, C.J., Rastogi, A., McGregor, C.G., Daly, R.C., Frye, R.L., Orszulak, T.A., Determinants of survival and recovery of left ventricular function after aortic valve replacement (1993) Ann Thorac Surg, 56, pp. 22-29. , discussion 29–30; Goncalves, A., Marcos-Alberca, P., Almeria, C., Feltes, G., Rodriguez, E., Hernandez-Antolin, R.A., Garcia, E., Zamorano, J.L., Acute left ventricle diastolic function improvement after transcatheter aortic valve implantation (2011) Eur J Echocardiogr, 12, pp. 790-797; Giannini, C., Petronio, A.S., Nardi, C., De Carlo, M., Guarracino, F., Delle Donne, M.G., Talini, E., Di Bello, V., Left ventricular reverse remodeling in percutaneous and surgical aortic bioprostheses: an echocardiographic study (2010) J Am Soc Echocardiogr, 24, pp. 28-36; Clavel, M.A., Webb, J.G., Rodes-Cabau, J., Masson, J.B., Dumont, E., De Larochelliere, R., Doyle, D., Pibarot, P., Comparison between transcatheter and surgical prosthetic valve implantation in patients with severe aortic stenosis and reduced left ventricular ejection fraction (2010) Circulation, 122, pp. 1928-1936; Berland, J., Cribier, A., Savin, T., Lefebvre, E., Koning, R., Letac, B., Percutaneous balloon valvuloplasty in patients with severe aortic stenosis and low ejection fraction. Immediate results and 1-year follow-up (1989) Circulation, 79, pp. 1189-1196; Bonow, R.O., Rosing, D.R., Maron, B.J., McIntosh, C.L., Jones, M., Bacharach, S.L., Green, M.V., Epstein, S.E., Reversal of left ventricular dysfunction after aortic valve replacement for chronic aortic regurgitation: influence of duration of preoperative left ventricular dysfunction (1984) Circulation, 70, pp. 570-579

PY - 2017

Y1 - 2017

N2 - Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis compared with patients with preserved LVEF. To evaluate the impact of early LVEF recovery in patients with baseline dysfunction on clinical outcomes after transcatheter aortic valve implantation (TAVI), we included all consecutive patients who underwent TAVI from the Italian ClinicalService registry with an LVEF of ≤45% at baseline who had 1-month LVEF data. Patients who experienced a previous coronary artery bypass graft, a previous valve replacement, or a previous myocardial infarction were excluded from the analysis. Therefore, 131 patients with an improvement in LVEF of

AB - Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis compared with patients with preserved LVEF. To evaluate the impact of early LVEF recovery in patients with baseline dysfunction on clinical outcomes after transcatheter aortic valve implantation (TAVI), we included all consecutive patients who underwent TAVI from the Italian ClinicalService registry with an LVEF of ≤45% at baseline who had 1-month LVEF data. Patients who experienced a previous coronary artery bypass graft, a previous valve replacement, or a previous myocardial infarction were excluded from the analysis. Therefore, 131 patients with an improvement in LVEF of

KW - acetylsalicylic acid

KW - bivalirudin

KW - clopidogrel

KW - heparin

KW - aged

KW - anticoagulant therapy

KW - aortic valve stenosis

KW - Article

KW - cardiovascular mortality

KW - cardiovascular parameters

KW - controlled study

KW - disease registry

KW - disease severity

KW - drug safety

KW - female

KW - heart left ventricle ejection fraction

KW - heart left ventricle failure

KW - high risk patient

KW - hospital discharge

KW - human

KW - major clinical study

KW - male

KW - percutaneous coronary intervention

KW - priority journal

KW - prognostic assessment

KW - survival rate

KW - transcatheter aortic valve implantation

KW - treatment outcome

KW - treatment response

KW - very elderly

KW - complication

KW - convalescence

KW - heart left ventricle function

KW - heart stroke volume

KW - mortality

KW - pathophysiology

KW - physiology

KW - prognosis

KW - retrospective study

KW - Aged

KW - Aged, 80 and over

KW - Aortic Valve Stenosis

KW - Female

KW - Humans

KW - Male

KW - Prognosis

KW - Recovery of Function

KW - Retrospective Studies

KW - Stroke Volume

KW - Transcatheter Aortic Valve Replacement

KW - Treatment Outcome

KW - Ventricular Dysfunction, Left

U2 - 10.1016/j.amjcard.2017.07.064

DO - 10.1016/j.amjcard.2017.07.064

M3 - Article

VL - 120

SP - 1639

EP - 1647

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 9

ER -