Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction

M. Angelillis, C. Giannini, M. De Carlo, M. Adamo, M. Nardi, A. Colombo, A. Chieffo, F. Bedogni, N. Brambilla, C. Tamburino, M. Barbanti, G. Bruschi, P. Colombo, A. Poli, P. Martina, R. Violini, P. Presbitero, A.S. Petronio

Research output: Contribution to journalArticle

Abstract

Patients with severe aortic stenosis and reduced left ventricular ejection fraction (LVEF) have a poor prognosis compared with patients with preserved LVEF. To evaluate the impact of early LVEF recovery in patients with baseline dysfunction on clinical outcomes after transcatheter aortic valve implantation (TAVI), we included all consecutive patients who underwent TAVI from the Italian ClinicalService registry with an LVEF of ≤45% at baseline who had 1-month LVEF data. Patients who experienced a previous coronary artery bypass graft, a previous valve replacement, or a previous myocardial infarction were excluded from the analysis. Therefore, 131 patients with an improvement in LVEF of
Original languageEnglish
Pages (from-to)1639-1647
Number of pages9
JournalAmerican Journal of Cardiology
Volume120
Issue number9
DOIs
Publication statusPublished - 2017

Keywords

  • acetylsalicylic acid
  • bivalirudin
  • clopidogrel
  • heparin
  • aged
  • anticoagulant therapy
  • aortic valve stenosis
  • Article
  • cardiovascular mortality
  • cardiovascular parameters
  • controlled study
  • disease registry
  • disease severity
  • drug safety
  • female
  • heart left ventricle ejection fraction
  • heart left ventricle failure
  • high risk patient
  • hospital discharge
  • human
  • major clinical study
  • male
  • percutaneous coronary intervention
  • priority journal
  • prognostic assessment
  • survival rate
  • transcatheter aortic valve implantation
  • treatment outcome
  • treatment response
  • very elderly
  • complication
  • convalescence
  • heart left ventricle function
  • heart stroke volume
  • mortality
  • pathophysiology
  • physiology
  • prognosis
  • retrospective study
  • Aged
  • Aged, 80 and over
  • Aortic Valve Stenosis
  • Female
  • Humans
  • Male
  • Prognosis
  • Recovery of Function
  • Retrospective Studies
  • Stroke Volume
  • Transcatheter Aortic Valve Replacement
  • Treatment Outcome
  • Ventricular Dysfunction, Left

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