Abstract
Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus. Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the eoesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immuncihistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. Results: Higher levels of COX-2 expression were associated with higher T stage (p = 0.008), higher N stage (p = 0.049), increased risk of tumour recurrence (p = 0.01) and poor survival (p = 200 was associated with a median survival of 10 months compared to 26 months with a score of
| Original language | English |
|---|---|
| Article number | 134 |
| Journal | BMC Cancer |
| Volume | 6 |
| DOIs | |
| Publication status | Published - May 19 2006 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
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Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus. / Bhandari, Pradeep; Bateman, Adrian C.; Mehta, Raj L.; Stacey, Bernard S F; Johnson, Penny; Cree, Ian A.; Di Nicolantonio, Federica; Patel, Praful.
In: BMC Cancer, Vol. 6, 134, 19.05.2006.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus
AU - Bhandari, Pradeep
AU - Bateman, Adrian C.
AU - Mehta, Raj L.
AU - Stacey, Bernard S F
AU - Johnson, Penny
AU - Cree, Ian A.
AU - Di Nicolantonio, Federica
AU - Patel, Praful
PY - 2006/5/19
Y1 - 2006/5/19
N2 - Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus. Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the eoesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immuncihistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. Results: Higher levels of COX-2 expression were associated with higher T stage (p = 0.008), higher N stage (p = 0.049), increased risk of tumour recurrence (p = 0.01) and poor survival (p = 200 was associated with a median survival of 10 months compared to 26 months with a score of
AB - Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus. Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the eoesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immuncihistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. Results: Higher levels of COX-2 expression were associated with higher T stage (p = 0.008), higher N stage (p = 0.049), increased risk of tumour recurrence (p = 0.01) and poor survival (p = 200 was associated with a median survival of 10 months compared to 26 months with a score of
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UR - http://www.scopus.com/inward/citedby.url?scp=33745315686&partnerID=8YFLogxK
U2 - 10.1186/1471-2407-6-134
DO - 10.1186/1471-2407-6-134
M3 - Article
C2 - 16712734
AN - SCOPUS:33745315686
VL - 6
JO - BMC Cancer
JF - BMC Cancer
SN - 1471-2407
M1 - 134
ER -