Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis

G. Flamini, G. Curigliano, C. Ratto, A. Astone, G. Ferretti, P. Nucera, L. Sofo, A. Sgambato, A. Boninsegna, F. Crucitti, A. Cittadini

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Abstract

p53 overexpression was studied by immunohistochemistry in 96 consecutive colorectal cancer patients, subdividing positive specimens according to two staining patterns: cytoplasmic or nuclear. Forty-seven per cent of the cases were p53 positive, a significant correlation being found with Dukes' stage (P = 0.0036). A prevalence of nuclear staining was observed in Dukes' B and cytoplasmic in Dukes' D stages. After 36 months, 23% of the patients had a recurrence, and 45% were p53 positive, all Dukes' C-D stage with cytoplasmic staining. The Kaplan-Meier curve showed a significant correlation between p53 cytoplasmic staining and disease-free survival period (P = 0.002). With respect to disease-free survival, the Cox proportional hazard regression test, comparing p53 positivity with Dukes' stage, showed the latter to be the most significant variable. In our series of patients, advanced Dukes' stage tumours were localised in the right colon, where a higher percentage of p53 positivity (67% versus 40% of the left side), as well as a higher frequency of cytoplasmic staining was observed. In conclusion, from the data obtained, a strong correlation between p53 cytoplasmic staining and patient prognosis is clearly indicated.

Original languageEnglish
Pages (from-to)802-806
Number of pages5
JournalEuropean Journal of Cancer
Volume32
Issue number5
DOIs
Publication statusPublished - May 1996

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Keywords

  • Colorectal cancer
  • Cytoplasm
  • Immunohistochemistry
  • p53 protein
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Flamini, G., Curigliano, G., Ratto, C., Astone, A., Ferretti, G., Nucera, P., Sofo, L., Sgambato, A., Boninsegna, A., Crucitti, F., & Cittadini, A. (1996). Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis. European Journal of Cancer, 32(5), 802-806. https://doi.org/10.1016/0959-8049(95)00625-7