Prognostic significance of fibrinopeptide a in survivors of cerebral infarction

Gianluca Landi, Riccardo Barbarotto, Alberto Morabito, D. Angelo Armando, Pier Mannuccio Mannucci

Research output: Contribution to journalArticlepeer-review


We measured levels of fibrinopeptide A, ß-thromboglobulin, and fibrinogen In the plasma of 27 patients 2 months after their first stroke. Concentrations of fibrinopeptide A, a sensitive index of in vivo hypercoagulability, were significantly higher in the 18 ischemic stroke patients than in 40 age-and sex-matched controls and in the six patients who experienced recurrence within 5 years than in the 12 who remained asymptomatic. On the contrary, fibrinopeptide A levels had no prognostic significance among the nine patients with hemorrhagic stroke. Concentrations of ß-thromboglobulin, an index of platelet activation, were higher in the 27 stroke patients than in the 40 controls, but this Index was not associated with stroke recurrence. Fibrinogen levels were not significantly higher in stroke patients than in controls. In a multivariate regression analysis of hemostatic and clinical variables, only fibrinopeptide A levels of >4 ng/ml were significantly related to cerebral infarction. Our results support the role of hypercoagulability in the recurrence of ischemic stroke and may allow identification of subjects at high risk for it. If confirmed in more patients, our results could provide a rationale for clinical trials of anticoagulant therapy In such patients.

Original languageEnglish
Pages (from-to)424-427
Number of pages4
Issue number3
Publication statusPublished - 1990


  • Beta-thromboglobulin
  • Blood coagulation
  • Cerebral infarction
  • Fibrinogen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing
  • Neuroscience(all)


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