Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol

Barbara Buldini; Frida Rizzati; Riccardo Masetti; Franca Fagioli; Giuseppe Menna; Concetta Micalizzi; Maria Caterina Putti; Carmelo Rizzari; Nicola Santoro; Marco Zecca; Silvia Disarò; Roberto Rondelli; Pietro Merli; Martina Pigazzi; Andrea Pession; Franco Locatelli; Giuseppe Basso

doi:10.1111/bjh.14523

Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol

Barbara Buldini, Frida Rizzati, Riccardo Masetti, Franca Fagioli, Giuseppe Menna, Concetta Micalizzi, Maria Caterina Putti, Carmelo Rizzari, Nicola Santoro, Marco Zecca, Silvia Disarò, Roberto Rondelli, Pietro Merli, Martina Pigazzi, Andrea Pession, Franco Locatelli, Giuseppe Basso

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Abstract

In children with acute myeloid leukaemia (AML), assessment of initial treatment response is an essential prognostic factor; methods more sensitive than morphology are still under evaluation. We report on the measurement of minimal residual disease (MRD), by multicolour flow-cytometry in one centralized laboratory, in 142 children with newly diagnosed AML enrolled in the Associazione Italiana di EmatoOncologia Pediatrica-AML 2002/01 trial. At the end of the first induction course, MRD was 1% in 51 patients. The 8-year disease-free survival (DFS) of 125 children in morphological complete remission and with MRD

Original language	English
Pages (from-to)	116-126
Number of pages	11
Journal	British Journal of Haematology
Volume	177
Issue number	1
DOIs	https://doi.org/10.1111/bjh.14523
Publication status	Published - Apr 1 2017

Keywords

Acute myeloid leukaemia
Flow-cytometry
Minimal residual disease
Paediatric; Risk group

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10.1111/bjh.14523

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Buldini, B., Rizzati, F., Masetti, R., Fagioli, F., Menna, G., Micalizzi, C., Putti, M. C., Rizzari, C., Santoro, N., Zecca, M., Disarò, S., Rondelli, R., Merli, P., Pigazzi, M., Pession, A., Locatelli, F., & Basso, G. (2017). Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol. British Journal of Haematology, 177(1), 116-126. https://doi.org/10.1111/bjh.14523

Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol. / Buldini, Barbara; Rizzati, Frida; Masetti, Riccardo; Fagioli, Franca; Menna, Giuseppe; Micalizzi, Concetta; Putti, Maria Caterina; Rizzari, Carmelo; Santoro, Nicola; Zecca, Marco; Disarò, Silvia; Rondelli, Roberto; Merli, Pietro; Pigazzi, Martina; Pession, Andrea; Locatelli, Franco; Basso, Giuseppe.

In: British Journal of Haematology, Vol. 177, No. 1, 01.04.2017, p. 116-126.

Research output: Contribution to journal › Article › peer-review

Buldini, B, Rizzati, F, Masetti, R, Fagioli, F, Menna, G, Micalizzi, C, Putti, MC, Rizzari, C, Santoro, N, Zecca, M, Disarò, S, Rondelli, R, Merli, P, Pigazzi, M, Pession, A, Locatelli, F & Basso, G 2017, 'Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol', British Journal of Haematology, vol. 177, no. 1, pp. 116-126. https://doi.org/10.1111/bjh.14523

Buldini, Barbara ; Rizzati, Frida ; Masetti, Riccardo ; Fagioli, Franca ; Menna, Giuseppe ; Micalizzi, Concetta ; Putti, Maria Caterina ; Rizzari, Carmelo ; Santoro, Nicola ; Zecca, Marco ; Disarò, Silvia ; Rondelli, Roberto ; Merli, Pietro ; Pigazzi, Martina ; Pession, Andrea ; Locatelli, Franco ; Basso, Giuseppe. / Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol. In: British Journal of Haematology. 2017 ; Vol. 177, No. 1. pp. 116-126.

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Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol

Abstract

Keywords

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