Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol

Barbara Buldini; Frida Rizzati; Riccardo Masetti; Franca Fagioli; Giuseppe Menna; Concetta Micalizzi; Maria Caterina Putti; Carmelo Rizzari; Nicola Santoro; Marco Zecca; Silvia Disarò; Roberto Rondelli; Pietro Merli; Martina Pigazzi; Andrea Pession; Franco Locatelli; Giuseppe Basso

doi:10.1111/bjh.14523

Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol

Barbara Buldini, Frida Rizzati, Riccardo Masetti, Franca Fagioli, Giuseppe Menna, Concetta Micalizzi, Maria Caterina Putti, Carmelo Rizzari, Nicola Santoro, Marco Zecca, Silvia Disarò, Roberto Rondelli, Pietro Merli, Martina Pigazzi, Andrea Pession, Franco Locatelli, Giuseppe Basso

Research output: Contribution to journal › Article

Abstract

In children with acute myeloid leukaemia (AML), assessment of initial treatment response is an essential prognostic factor; methods more sensitive than morphology are still under evaluation. We report on the measurement of minimal residual disease (MRD), by multicolour flow-cytometry in one centralized laboratory, in 142 children with newly diagnosed AML enrolled in the Associazione Italiana di EmatoOncologia Pediatrica-AML 2002/01 trial. At the end of the first induction course, MRD was 1% in 51 patients. The 8-year disease-free survival (DFS) of 125 children in morphological complete remission and with MRD

Original language	English
Pages (from-to)	116-126
Number of pages	11
Journal	British Journal of Haematology
Volume	177
Issue number	1
DOIs	https://doi.org/10.1111/bjh.14523
Publication status	Published - Apr 1 2017

Fingerprint

Keywords

Acute myeloid leukaemia
Flow-cytometry
Minimal residual disease
Paediatric; Risk group

Cite this

Buldini, B., Rizzati, F., Masetti, R., Fagioli, F., Menna, G., Micalizzi, C., Putti, M. C., Rizzari, C., Santoro, N., Zecca, M., Disarò, S., Rondelli, R., Merli, P., Pigazzi, M., Pession, A., Locatelli, F., & Basso, G. (2017). Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol. British Journal of Haematology, 177(1), 116-126. https://doi.org/10.1111/bjh.14523

Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol. / Buldini, Barbara; Rizzati, Frida; Masetti, Riccardo; Fagioli, Franca; Menna, Giuseppe; Micalizzi, Concetta; Putti, Maria Caterina; Rizzari, Carmelo; Santoro, Nicola; Zecca, Marco; Disarò, Silvia; Rondelli, Roberto; Merli, Pietro; Pigazzi, Martina; Pession, Andrea; Locatelli, Franco; Basso, Giuseppe.

In: British Journal of Haematology, Vol. 177, No. 1, 01.04.2017, p. 116-126.

Research output: Contribution to journal › Article

Buldini, B, Rizzati, F, Masetti, R, Fagioli, F, Menna, G, Micalizzi, C, Putti, MC, Rizzari, C, Santoro, N, Zecca, M, Disarò, S, Rondelli, R, Merli, P, Pigazzi, M, Pession, A, Locatelli, F & Basso, G 2017, 'Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol', British Journal of Haematology, vol. 177, no. 1, pp. 116-126. https://doi.org/10.1111/bjh.14523

Buldini, Barbara ; Rizzati, Frida ; Masetti, Riccardo ; Fagioli, Franca ; Menna, Giuseppe ; Micalizzi, Concetta ; Putti, Maria Caterina ; Rizzari, Carmelo ; Santoro, Nicola ; Zecca, Marco ; Disarò, Silvia ; Rondelli, Roberto ; Merli, Pietro ; Pigazzi, Martina ; Pession, Andrea ; Locatelli, Franco ; Basso, Giuseppe. / Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol. In: British Journal of Haematology. 2017 ; Vol. 177, No. 1. pp. 116-126.

@article{097902cb2d4a41528fb7e0c561bb2ab2,

title = "Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol",

abstract = "In children with acute myeloid leukaemia (AML), assessment of initial treatment response is an essential prognostic factor; methods more sensitive than morphology are still under evaluation. We report on the measurement of minimal residual disease (MRD), by multicolour flow-cytometry in one centralized laboratory, in 142 children with newly diagnosed AML enrolled in the Associazione Italiana di EmatoOncologia Pediatrica-AML 2002/01 trial. At the end of the first induction course, MRD was 1% in 51 patients. The 8-year disease-free survival (DFS) of 125 children in morphological complete remission and with MRD ",

keywords = "Acute myeloid leukaemia, Flow-cytometry, Minimal residual disease, Paediatric; Risk group",

author = "Barbara Buldini and Frida Rizzati and Riccardo Masetti and Franca Fagioli and Giuseppe Menna and Concetta Micalizzi and Putti, {Maria Caterina} and Carmelo Rizzari and Nicola Santoro and Marco Zecca and Silvia Disar{\`o} and Roberto Rondelli and Pietro Merli and Martina Pigazzi and Andrea Pession and Franco Locatelli and Giuseppe Basso",

year = "2017",

month = apr

day = "1",

doi = "10.1111/bjh.14523",

language = "English",

volume = "177",

pages = "116--126",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley & Sons, Ltd (10.1111)",

number = "1",

}

TY - JOUR

T1 - Prognostic significance of flow-cytometry evaluation of minimal residual disease in children with acute myeloid leukaemia treated according to the AIEOP-AML 2002/01 study protocol

AU - Buldini, Barbara

AU - Rizzati, Frida

AU - Masetti, Riccardo

AU - Fagioli, Franca

AU - Menna, Giuseppe

AU - Micalizzi, Concetta

AU - Putti, Maria Caterina

AU - Rizzari, Carmelo

AU - Santoro, Nicola

AU - Zecca, Marco

AU - Disarò, Silvia

AU - Rondelli, Roberto

AU - Merli, Pietro

AU - Pigazzi, Martina

AU - Pession, Andrea

AU - Locatelli, Franco

AU - Basso, Giuseppe

PY - 2017/4/1

Y1 - 2017/4/1

N2 - In children with acute myeloid leukaemia (AML), assessment of initial treatment response is an essential prognostic factor; methods more sensitive than morphology are still under evaluation. We report on the measurement of minimal residual disease (MRD), by multicolour flow-cytometry in one centralized laboratory, in 142 children with newly diagnosed AML enrolled in the Associazione Italiana di EmatoOncologia Pediatrica-AML 2002/01 trial. At the end of the first induction course, MRD was 1% in 51 patients. The 8-year disease-free survival (DFS) of 125 children in morphological complete remission and with MRD

AB - In children with acute myeloid leukaemia (AML), assessment of initial treatment response is an essential prognostic factor; methods more sensitive than morphology are still under evaluation. We report on the measurement of minimal residual disease (MRD), by multicolour flow-cytometry in one centralized laboratory, in 142 children with newly diagnosed AML enrolled in the Associazione Italiana di EmatoOncologia Pediatrica-AML 2002/01 trial. At the end of the first induction course, MRD was 1% in 51 patients. The 8-year disease-free survival (DFS) of 125 children in morphological complete remission and with MRD

KW - Acute myeloid leukaemia

KW - Flow-cytometry

KW - Minimal residual disease

KW - Paediatric; Risk group

U2 - 10.1111/bjh.14523

DO - 10.1111/bjh.14523

M3 - Article

VL - 177

SP - 116

EP - 126

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -

Access to Document

10.1111/bjh.14523