Prognostic significance of free-floating right heart thromboemboli in acute pulmonary embolism: Results from the Italian Pulmonary Embolism Registry

Franco Casazza, Cecilia Becattini, Emanuele Guglielmelli, Irene Floriani, Vincenzo Morrone, Carla Caponi, Luigi Pizzorno, Luca Masotti, Amedeo Bongarzoni, Luigi Pignataro

Research output: Contribution to journalArticlepeer-review

Abstract

The exact prevalence of mobile right heart thromboemboli (RHTh) in patients with pulmonary embolism (PE) is unknown, depending upon PE severity and the use of early echocardiography. Similarly, the mortality rate is variable, though RHTh detection appears to substantially increase the risk of death in patients with PE. The aim of this study was to assess the prevalence of RHTh in different risk categories in a wide series of patients with PE, and to analyse the effect of RHTh on in-hospital mortality. Among 1,716 patients enrolled in the Italian Pulmonary Embolism Registry, 1,275 (13.3% at high risk, 59.3% at intermediate risk and 27.4% at low risk) had echocardiography within 48 hours from hospital admission and entered the study. Overall, RHTh were detected in 57 patients (4.5%, at admission echocardiography in 88%): in 27/169 (16%) high-risk, in 29/756 (3.8%) intermediate-risk and 1/350 (0.3%) low-risk patients, respectively. At multivariate analysis, only advanced age (odds ratio [OR] 1.61, 95% confidence [CI] 1.27-2.03, p

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalThrombosis and Haemostasis
Volume111
Issue number1
DOIs
Publication statusPublished - Oct 2 2013

Keywords

  • Prognosis
  • Pulmonary embolism
  • Right heart free-floating thromboemboli

ASJC Scopus subject areas

  • Hematology

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