Prognostic significance of heart rate variability in post-myocardial infarction patients in the fibrinolytic era: The GISSI-2 results

Giulio Zuanetti, J. M M Neilson, Roberto Latini, Eugenio Santoro, Aldo P. Maggioni, David J. Ewing

Research output: Contribution to journalArticle

Abstract

Background: Studies performed before the introduction of fibrinolysis showed that a low heart rate variability (HRV) is associated with higher mortality in post-myocardial infarction (MI) patients. We evaluated whether HRV adds information relevant to risk stratification in patients treated with fibrinolysis as well. Methods and Results: From 24-hour ECG recordings obtained at discharge in patients treated with recombinant tissue type plasminogen activator or streptokinase, we measured several time-domain indexes of HRV: standard deviation (SDNN), root-mean-square of successive differences (RMSSD), and number of RR interval increases >50 ms ('NN50+'). The prognostic value of HRV for total and cardiovascular mortality was assessed. Of 567 patients with valid recordings, 52 (9.1%) died during the 1000 days of follow-up, 44 (7.8%) of cardiovascular causes. All indexes of low HRV were able to identify patients (16% to 18% of total population) with a higher total mortality (20.8% to 24.2% versus 6.0% to 6.8%, depending on index used). The independent predictive value of low HRV was confirmed by the adjusted analysis with the following relative risks: NN50+, 3.5 (95% CI, 1.9 to 6.7); SDNN, 3.0 (95% CI, 1.55 to 5.9); and RMSSD, 2.8 (95% CI, 1.5 to 5.3). Advanced age, previous MI, Killip class at entry, and use of digitalis were also independent predictors. Similar data were obtained for cardiovascular mortality. Conclusions: Time-domain indexes of HRV retain their in dependent prognostic significance even in post-MI patients of all ages treated with fibrinolysis.

Original languageEnglish
Pages (from-to)432-436
Number of pages5
JournalCirculation
Volume94
Issue number3
Publication statusPublished - 1996

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Keywords

  • electrocardiography
  • fibrinolysis
  • heart rate
  • myocardial infarction
  • prognosis

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Zuanetti, G., Neilson, J. M. M., Latini, R., Santoro, E., Maggioni, A. P., & Ewing, D. J. (1996). Prognostic significance of heart rate variability in post-myocardial infarction patients in the fibrinolytic era: The GISSI-2 results. Circulation, 94(3), 432-436.