Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation

E. Holler, M. G. Roncarolo, R. Hintermeier-Knabe, G. Eissner, B. Ertl, U. Schulz, H. Knabe, H. J. Kolb, R. Andreesen, W. Wilmanns

Research output: Contribution to journalArticlepeer-review

Abstract

IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P <0.01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalBone Marrow Transplantation
Volume25
Issue number3
Publication statusPublished - 2000

Keywords

  • Bone marrow transplantation
  • GVHD
  • IL-10
  • TNF-α

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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