TY - JOUR
T1 - Prognostic significance of interleukin-6 measurement in the diagnosis of acute myocardial infarction in emergency department
AU - Ferroni, Patrizia
AU - Rosa, Antonello
AU - Di Franco, Manuela
AU - Palmirotta, Raffaele
AU - Guadagni, Fiorella
AU - Davì, Giovanni
AU - Bertazzoni, Giuliano
AU - Basili, Stefania
PY - 2007/6
Y1 - 2007/6
N2 - Background: Markers of inflammation may predict both coronary artery disease (CAD) and adverse outcomes in patients with known CAD. Here, we investigated the role of interleukin-6 (IL-6) in the "triage" and risk assessment of patients admitted to emergency department (ED). Methods: Serum IL-6 and high sensitivity C-reactive protein (hs-CRP) levels were prospectively evaluated in 88 patients with a history of precordial chest pain or shortness of breath of recent onset (<6 h). Results: Of the 88 patients, 21% were discharged from the ED with diagnosis of non-ischemic chest pain (NICP), 39% had a final diagnosis of unstable angina (UA) and 40% experienced an acute myocardial infarction (AMI). Median IL-6 (p <0.001) and hs-CRP (p <0.01) levels on admission were significantly increased in patients with AMI compared with patients with NICP or UA. IL-6 levels correlated with hs-CRP (p <0.01). Multivariate analyses including known risk factors showed that elevated creatine kinase-MB (p <0.05) and IL-6 levels (p <0.01) were independently associated with a final diagnosis of AMI. Elevated IL-6 levels significantly predicted the risk of AMI (OR = 2.47, p = 0.006) in chest pain-enzyme negative patients. Conclusions: IL-6 may behave as an adjunctive diagnostic tool to assist in the risk assessment of enzyme-negative patients with precordial chest pain of recent onset.
AB - Background: Markers of inflammation may predict both coronary artery disease (CAD) and adverse outcomes in patients with known CAD. Here, we investigated the role of interleukin-6 (IL-6) in the "triage" and risk assessment of patients admitted to emergency department (ED). Methods: Serum IL-6 and high sensitivity C-reactive protein (hs-CRP) levels were prospectively evaluated in 88 patients with a history of precordial chest pain or shortness of breath of recent onset (<6 h). Results: Of the 88 patients, 21% were discharged from the ED with diagnosis of non-ischemic chest pain (NICP), 39% had a final diagnosis of unstable angina (UA) and 40% experienced an acute myocardial infarction (AMI). Median IL-6 (p <0.001) and hs-CRP (p <0.01) levels on admission were significantly increased in patients with AMI compared with patients with NICP or UA. IL-6 levels correlated with hs-CRP (p <0.01). Multivariate analyses including known risk factors showed that elevated creatine kinase-MB (p <0.05) and IL-6 levels (p <0.01) were independently associated with a final diagnosis of AMI. Elevated IL-6 levels significantly predicted the risk of AMI (OR = 2.47, p = 0.006) in chest pain-enzyme negative patients. Conclusions: IL-6 may behave as an adjunctive diagnostic tool to assist in the risk assessment of enzyme-negative patients with precordial chest pain of recent onset.
KW - Inflammation
KW - Interleukin-6
KW - Myocardial infarction
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U2 - 10.1016/j.cca.2007.03.002
DO - 10.1016/j.cca.2007.03.002
M3 - Article
C2 - 17408606
AN - SCOPUS:34248193700
VL - 381
SP - 151
EP - 156
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 2
ER -