Prognostic significance of laminin production in relation with its receptor expression in human breast carcinomas

Rita Pellegrini, Stefania Martignone, Elda Tagliabue, Dorina Belotti, Rosaria Bufalino, Natale Cascinelli, Sylvie Ménard, Maria Ines Colnaghi

Research output: Contribution to journalArticlepeer-review

Abstract

Laminin is a basement membrane glycoprotein whose expression has been widely related to cancer progression. Laminin production by primary breast carcinomas was investigated using immunohistochemistry on archival specimens from a retrospective series with long term follow-up. Laminin production was found to be independent of the clinical and pathological variables analyzed, whereas a statistically significant direct association with the expression of the laminin receptor and a negative association with the differentiation-related antigen Ca-MBr8 were observed. Survival analysis indicated that laminin positivity by itself has no prognostic significance. However, when analyzed together with the laminin receptor expression, laminin was associated with a good prognosis in receptor-negative tumors and with the worst prognosis in receptor-positive tumors.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalBreast Cancer Research and Treatment
Volume35
Issue number2
DOIs
Publication statusPublished - Aug 1995

Keywords

  • breast cancer
  • laminin
  • laminin receptor
  • metastasis
  • prognosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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