TY - JOUR
T1 - Prognostic significance of lymphography in stage IIIs Hodgkin's disease (HD)
AU - Mazza, Patrizio
AU - Miniaci, Gino
AU - Lauria, Francesco
AU - Gobbi, Marco
AU - Emiliani, Ermanno
AU - Barbieri, Enza
AU - Neri, Stefano
AU - Querzani, Piero
AU - Fiacchini, Mauro
AU - Tura, Sante
PY - 1984
Y1 - 1984
N2 - Ninety-six patients with pathological stage IIIs Hodgkin's disease, uniformly treated with six cycles of MOPP and TNI, were retrospectively analysed in an effort to determine whether the lymphographic aspect of lymph nodes influence the prognosis. Case material was grouped according to the presence of lymph nodes less than 3 cm in diameter or larger at lymphography. Five-year survival and disease-free survival were 85 and 78% for patients with small lymph node involvement, compared to 48 and 30% for patients with larger lymph nodes. The comparative analysis between the lymphographic aspect and other prognostic factors shows that large lymphographic involvement is strongly correlated with the presence of large spleen involvement (P <0.0000029), followed by stage III2 (P <0.000612), followed by ≥5 involved sites (P <0.012), followed by age >40 yr (P <0.047). Conversely, no significant correlation was found with symptoms, histology and mediastinal involvement. Modifications of current treatment for both large and small lymph node involvement are discussed.
AB - Ninety-six patients with pathological stage IIIs Hodgkin's disease, uniformly treated with six cycles of MOPP and TNI, were retrospectively analysed in an effort to determine whether the lymphographic aspect of lymph nodes influence the prognosis. Case material was grouped according to the presence of lymph nodes less than 3 cm in diameter or larger at lymphography. Five-year survival and disease-free survival were 85 and 78% for patients with small lymph node involvement, compared to 48 and 30% for patients with larger lymph nodes. The comparative analysis between the lymphographic aspect and other prognostic factors shows that large lymphographic involvement is strongly correlated with the presence of large spleen involvement (P <0.0000029), followed by stage III2 (P <0.000612), followed by ≥5 involved sites (P <0.012), followed by age >40 yr (P <0.047). Conversely, no significant correlation was found with symptoms, histology and mediastinal involvement. Modifications of current treatment for both large and small lymph node involvement are discussed.
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U2 - 10.1016/0277-5379(84)90058-0
DO - 10.1016/0277-5379(84)90058-0
M3 - Article
C2 - 6542008
AN - SCOPUS:0021710627
VL - 20
SP - 1393
EP - 1399
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 11
ER -