Prognostic significance of monocytosis in patients with myeloproliferative disorders

Miloslav Beran, Yu Shen, Francesco Onida, Sijin Wen, Hagop Kantarjian, Elihu Estey

Research output: Contribution to journalArticle

Abstract

Based on clinical and pathological findings, chronic myelomonocytic leukemia (CMML) differs from other myeloproliferative/myelodysplastic disorders by its hallmark, monocytosis. It is unknown whether the presence of monocytosis and the diagnosis of CMML carry a prognostic significance. The present study aimed to determine whether the survival of patients with CMML differs from that of patients with BCR/ ABL-negative CML or Ph1-, BCR/ABL-unknown CML, once other potentially prognostic variables have been accounted for. The records of 485 patients with myeloproliferative/myelodysplastic disorders [CMML, n = 304; BCR/ABL-negative CML, n = 107; Ph1-, BCR/ABL unknown, n = 74] were analysed. Of the covariates found to be significantly (P <0.01) associated with survival in univariate and multivariate analyses, the following remainedpredictive and adversely associated with survival in univariate and multivariate analysies, the following remained predictive and adversely associated with survival, after accounting for the influence of other covaries: increasing age, white blood cell count, platelets, bone marrow blasts and cellularity, decreasing hemoglobin, abnormal karyotype, and diagnosis of CMML. The diagnosis of CMML is prognostically significant and independently associated with a shorter survival and a higher risk of death than BCR/ ABL-negative CML or Ph1- BCR/ABL-unknown CML.

Original languageEnglish
Pages (from-to)417-423
Number of pages7
JournalLeukemia and Lymphoma
Volume47
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • MPD
  • Prognostic significance of monocytosis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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