Prognostic Significance of Myocardial Ischemia During Dobutamine Stress Echocardiography in Asymptomatic Patients With Diabetes Mellitus and No Prior History of Coronary Events

Fabiola B. Sozzi, Abdou Elhendy, Vittoria Rizzello, Elena Biagini, Ron T. van Domburg, Arend F L Schinkel, Jeroen J. Bax, Eleni Vourvouri, Gian Battista Danzi, Don Poldermans

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic significance of myocardial ischemia assessed by dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus who have no previous coronary artery disease remains unclear. We assessed the value of dobutamine stress echocardiography for risk stratification in 161 asymptomatic patients with type 2 diabetes (mean 62 ± 12 years of age; 96 men) who had no previous myocardial infarction or revascularization. End point during follow-up was hard cardiac events (cardiac death and nonfatal myocardial infarction). Ischemia was detected in 45 patients (28%). During a median follow-up of 5 years, 40 patients (25%) died (18 cardiac deaths) and 7 patients had nonfatal myocardial infarction (25 hard cardiac events). An abnormal dobutamine stress echocardiogram was associated with a higher mortality compared with a normal dobutamine stress echocardiogram (p = 0.03). In an incremental multivariate analysis model, clinical predictors of hard cardiac events were age and hypercholesterolemia. Ischemia was incremental to the clinical parameters. In conclusion, myocardial ischemia is an independent predictor of cardiac events in asymptomatic diabetic patients with no previous coronary artery disease.

Original languageEnglish
Pages (from-to)1193-1195
Number of pages3
JournalThe American Journal of Cardiology
Volume99
Issue number9
DOIs
Publication statusPublished - May 1 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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