TY - JOUR
T1 - Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer
AU - Fanetti, Giuseppe
AU - Alterio, Daniela
AU - Marvaso, Giulia
AU - Gandini, Sara
AU - Rojas, Damaris Patricia
AU - Gobitti, Carlo
AU - Minatel, Emilio
AU - Revelant, Alberto
AU - Caroli, Angela
AU - Francia, Claudia Maria
AU - Alessandro, Ombretta
AU - Pepa, Matteo
AU - Gugliandolo, Simone Giovanni
AU - Starzyńska, Anna
AU - Polesel, Jerry
AU - Vaccher, Emanuela
AU - Cossu Rocca, Maria
AU - Tagliabue, Marta
AU - Ansarin, Mohssen
AU - Lupato, Valentina
AU - Giacomarra, Vittorio
AU - De Paoli, Antonino
AU - Orecchia, Roberto
AU - Franchin, Giovanni
AU - Jereczek-Fossa, Barbara Alicja
N1 - Funding Information:
This study was partially supported by Associazione Italiana per la Ricerca sul Cancro (AIRC), project IG‐14300 “Carbon ions boost followed by pelvic photon intensity‐modulated radiotherapy for high‐risk prostate cancer,” registered at ClinicalTrials.gov (NCT02672449), approved by IEO R86/14‐ IEO 98 and by Accuray Inc. project entitled “Data collection and analysis of Tomotherapy and CyberKnife breast clinical studies, breast physics studies and prostate study.” The Sponsors did not play any role in the study design, collection, analysis and interpretation of data, nor in the writing of the manuscript, nor in the decision to submit the manuscript for publication.
Funding Information:
Matteo Pepa has received a research grant from Accuray Inc., and Simone Giovanni Gugliandolo has received a research grant from AIRC.
Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Aim: To evaluate the role of baseline neutrophil-to-lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. Patients and methods: A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression-free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed. Results: Seventy-seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow-up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two-year OS was 91% and 81% in pts with NLR <3 and ≥3, respectively. Conclusion: A baseline NLR ≥ 3 at treatment initiation represented a negative prognostic marker for OPC treated with definitive CRT. These results are in line with literature data, and prognostic value of NLR has been confirmed restaging our cohort with new TNM staging (8th ed.). Therefore, NLR could be considered a valuable biomarker for risk stratification in pts with OPC.
AB - Aim: To evaluate the role of baseline neutrophil-to-lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. Patients and methods: A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression-free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed. Results: Seventy-seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow-up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two-year OS was 91% and 81% in pts with NLR <3 and ≥3, respectively. Conclusion: A baseline NLR ≥ 3 at treatment initiation represented a negative prognostic marker for OPC treated with definitive CRT. These results are in line with literature data, and prognostic value of NLR has been confirmed restaging our cohort with new TNM staging (8th ed.). Therefore, NLR could be considered a valuable biomarker for risk stratification in pts with OPC.
KW - biomarkers
KW - HPV status
KW - neutrophil-to-lymphocyte ratio
KW - oropharyngeal cancer
KW - radiotherapy
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U2 - 10.1111/odi.13366
DO - 10.1111/odi.13366
M3 - Article
C2 - 32315470
AN - SCOPUS:85084452779
VL - 26
SP - 1384
EP - 1392
JO - Oral Diseases
JF - Oral Diseases
SN - 1354-523X
IS - 7
ER -